Urinary albumin excretion rate (AER) in newly-diagnosed type 2 Indian diabetic patients is associated with central obesity and hyperglycaemia

Yajnik, C.S.; Naik, Sadanand; Raut, K.N.; Khade, Avinash; Bhat, Dattatray; Nagarkar, V. D.; Deshpande, Jyoti A; Shelgikar, K.M.

doi:10.1016/0168-8227(92)90044-r

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…In the present study, the prevalence of MAU and macroproteinuria are 25.5% and 16.2%, respectively. This prevalence of MAU is comparable to that of Viswanathan et al, 19 CURES 45, 21 and Yajnik et al 30 The larger MAP Study 29 showed a much higher prevalence of 39.8%. However, this study included hypertensive type 2 diabetes patients.…”

Section: Discussionsupporting

confidence: 88%

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Prevalence of Microalbuminuria Among Patients with Type 2 Diabetes Mellitus—A Hospital-Based Study from North India

Kanakamani

Ammini

Gupta

et al. 2010

Diabetes Technology & Therapeutics

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Section: Discussionsupporting

confidence: 88%

“…Yajnik et al 30 reported from Pune that 23% of noninsulin-dependent DM and 19% of impaired glucose tolerance patients had MAU. A large clinic-based study done by Varghese et al 20 in Chennai reported the prevalence of MAU to be 36.6%.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of Microalbuminuria Among Patients with Type 2 Diabetes Mellitus—A Hospital-Based Study from North India

Kanakamani

Ammini

Gupta

et al. 2010

Diabetes Technology & Therapeutics

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“…As mentioned previously, 15% of Pima Indians with IGT have microalbuminuria (7). In other studies in subjects with IGT, 9.9% of Australians (15), 14 (16) and 24% (17) of Japanese, 11.8% of Koreans (18), and 19% of Indians had microalbuminuria (19). …”

Section: Discussionmentioning

confidence: 81%

Changes in Albumin Excretion in the Diabetes Prevention Program

Molitch¹,

Barrett‐Connor²,

Crandall³

et al. 2009

Diabetes Care

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OBJECTIVE -Increased urinary albumin excretion rates have been linked to nephropathy and macrovascular disease. We here describe the baseline prevalence and effect of Diabetes Prevention Program (DPP) interventions on the development and reversal of elevated albumin excretion.RESEARCH DESIGN AND METHODS -Urine albumin-to-creatinine ratios (ACRs) were calculated from untimed urine collections. Analyses compared participants by treatment group, diabetes and hypertension status, and use of ACE inhibitors or angiotensin II receptor blockers (ARBs).RESULTS -Elevated ACR levels (Ն30 mg/g creatinine) were present at baseline in 198 (6.2%) of 3,188 participants: placebo 5.3%, metformin 6.5%, and intensive lifestyle (ILS) 6.8%. Of the 2,802 with ACR measurements at baseline and at the end of the study, the percentage with elevated levels declined (incident and regression) from 6.2 to 6.1%, with no significant differences between the groups even with adjustment for ACE inhibitor and ARB use. The odds of developing an elevated ACR were 59% higher for a participant who developed diabetes compared with one who did not.CONCLUSIONS -At entry into the DPP, an elevated ACR was present in 6.2%. Despite the marked decrease in progression to diabetes and the improvement in insulin resistance and other cardiovascular risk markers in the ILS and metformin groups, there was no improvement in ACR, on average, in those two groups. However, the frequency of an elevated ACR was higher in participants who developed diabetes. An increased ACR may have multiple causes, thus obscuring the improvements that might have been expected with the reduction in insulin resistance seen in the DPP. Diabetes Care 32:720-

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“…Nonetheless, those who have relatively more skeletal muscle and physical fitness have lower risk of cardiovascular disease. 8,9 From birth, Asian Indians have less muscle mass and have a more central distribution of body fat than Europeans, 10 which is associated with increased risk of type 2 diabetes and ischemic heart disease. 11 In contrast, Polynesians (Pacific and Maori) have higher bone mass and muscle mass than Europeans and Asians of the same size.…”

Section: Introductionmentioning

confidence: 99%

BMI, fat and muscle differences in urban women of five ethnicities from two countries

et al. 2007

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Urinary albumin excretion rate (AER) in newly-diagnosed type 2 Indian diabetic patients is associated with central obesity and hyperglycaemia

Cited by 11 publications

References 19 publications

Prevalence of Microalbuminuria Among Patients with Type 2 Diabetes Mellitus—A Hospital-Based Study from North India

Prevalence of Microalbuminuria Among Patients with Type 2 Diabetes Mellitus—A Hospital-Based Study from North India

Changes in Albumin Excretion in the Diabetes Prevention Program

BMI, fat and muscle differences in urban women of five ethnicities from two countries

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