Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus

Aktas, Gülali; Koçak, Mehmet Zahid; Bilgin, Satılmış; Tel, Burçin Meryem Atak; Duman, Tuba Taslamacıoğlu; Kurtkulağı, Özge

doi:10.1080/13685538.2019.1678126

Cited by 112 publications

(83 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are other studies in literature reported association between increased UHR and various clinical conditions. Serum UHR has been suggested as a valuable predictor of diabetic control in men with type 2 diabetes mellitus [11]. Moreover, plasma glucose and glycated hemoglobin (HbA1c) levels were found to be correlated with UHR levels [11].…”

Section: Discussionmentioning

confidence: 99%

“…Serum UHR has been suggested as a valuable predictor of diabetic control in men with type 2 diabetes mellitus [11]. Moreover, plasma glucose and glycated hemoglobin (HbA1c) levels were found to be correlated with UHR levels [11]. Continuous low grade inflammation is a characteristic of type 2 diabetes mellitus [18].…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with hyperuricemia are accompanied by metabolic comorbidity; diabetes, hypertension, and metabolic syndrome [9]. The rate of uric acid and HDL cholesterol; so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions, including, metabolic syndrome [10], diabetes mellitus [11] and hepatosteatosis [12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio

Kurtkulağı

Tel

Kahveci

et al. 2021

Romanian Journal of Internal Medicine

Self Cite

View full text Add to dashboard Cite

Background . Hashimoto’s thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol; so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions diseases. We aimed to compare UHR and other laboratory parameters of the patients with HT to those values in healthy controls. Methods . The patients whom diagnosed with HT by medical history, physical examination, elevated thyroid autoantibodies in serum and characteristic sonographic findings in outpatient internal medicine clinics of our institution were enrolled to the present retrospective study. Age and sex matched healthy volunteers were enrolled as controls. UHR of the HT patients and control subjects were compared. Results . Mean UHR of the HT group was 11% ± 4 %, while UHR of the control group was 8% ± 2% (p<0.001). UHR was significantly and positively correlated with thyroid stimulating hormone (TSH) (r=0.26, p=0.01) and negatively correlated with free T4 (FT4) (r=-0.22, p=0.04) levels. The sensitivity and specificity of the UHR level greater than 8.3% were 74% and 52%, respectively (AUC: 0.74, p<0.001, 95% CI: 0.64-0.84). Conclusion . We suggest that UHR is a reliable and useful marker for HT. Therefore, it may be helpful in establishing the diagnosis of HT in addition to other diagnostic tools.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio

Kurtkulağı

Tel

Kahveci

et al. 2021

Romanian Journal of Internal Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…NFκB is involved in pathological brain inflammation and is associated with the expression of proinflammatory cytokines [ 26 ]. These proinflammatory markers are elevated in patients with type 2 DM, including C-reactive protein [ 27 ], neutrophil/lymphocyte ratio [ 28 ], platelet/lymphocyte ratio [ 29 ], uric acid/HDL ratio [ 30 ], and mean platelet volume [ 31 ]. Our study showed hs-CRP was higher in MCI diabetics compared to non-MCI diabetics.…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study

Zhang

Zhu

et al. 2021

International Journal of Endocrinology

View full text Add to dashboard Cite

Objectives. Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM). Methods. A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Their blood sample was examined for the level of melatonin and other biochemical parameters. Results. Melatonin concentration was decreased in MCI patients to non-MCI patients ( P < 0.001). Melatonin level was negatively correlated with age (r = −0.202; P = 0.001), diabetes duration (r = −0.282; P < 0.001), serum HbA1c (r = −0.195; P = 0.002), hs-CRP (r = −0.324; P < 0.001), and TSH (r = −0.184; P = 0.004) levels and positively correlated with MoCA score, serum HDL-C (r = 0.145; P < 0.001), FT3 (r = 0.241; P < 0.001), and FT4 (r = 0.169; P = 0.008) levels. The multivariable analysis indicated that fewer years of formal education, longer diabetes duration, higher serum HbA1c, higher serum hs-CRP, and lower serum melatonin are the predisposing factors for MCI. Conclusion. Lower melatonin level was associated with cognitive impairment in patients with T2DM. Melatonin might serve as a potential protective molecule against cognitive dysfunction in T2DM.

show abstract

“…In diabetic patients, poorly controlled diabetic subjects have lower HDL compared to the well-controlled diabetic patients. 22 Meanwhile, HDL of the subjects with diabetic nephropathy have lower levels of HDL compared to the diabetic patients without diabetic nephropathy. 23 These findings were considered to be associated with increased inflammatory burden.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Lipid Metabolism in Untreated Patients with Anti-MDA5 Antibody-Positive

Huang¹,

Ren²,

Luo³

et al. 2021

IJGM

View full text Add to dashboard Cite

Objective Clinical characterization of lipid metabolism in untreated patients with anti-melanoma differentiation-associated gene 5 antibodies-positive (anti-MDA5 + ). Methods Body-mass index (BMI), autoantibodies, lipid levels, and serum ferritin levels in 57 anti-MDA5 + patients were determined in the Department of Rheumatology and Immunology of the Second Affiliated Hospital of Chongqing Medical University. Results Plasma high-density lipoprotein (HDL) and apolipoprotein A1 (ApoA1) levels were significantly lower in deceased group than in the survival group (P < 0.05). Plasma levels of HDL and ApoA1 were significantly lower in patients who were simultaneously anti-MDA5 + and anti-Ro-52 + than in patients who were anti-MDA5 + alone (P < 0.05). Plasma levels of total cholesterol, low-density lipoprotein, HDL, and ApoA1 were significantly decreased in patients with high levels of serum ferritin compared with patients with low levels (P < 0.05). There were no significant differences in blood lipid levels between patients grouped according to BMI. Conclusion 1) HDL and ApoA1 levels are important indicators of poor prognosis in anti-MDA5 + patients; 2) Dysregulated lipid metabolism in anti-MDA5 + patients is closely associated with anti-Ro-52 antibody and ferritin levels but independent of BMI; 3) HDL involvement in inflammation and immune regulation merits close attention by rheumatologists.

show abstract

Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus

Cited by 112 publications

References 29 publications

Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio

Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study

Clinical Characteristics of Lipid Metabolism in Untreated Patients with Anti-MDA5 Antibody-Positive

Contact Info

Product

Resources

About