Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease

Kanellis, John; Kang, Duk Hee

doi:10.1016/j.semnephrol.2004.09.007

Cited by 364 publications

(313 citation statements)

References 37 publications

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“…Regular exercise may have a favorable effect on suppressing abdominal fat accumulation and inflammatory markers (29). Serum CRP concentrations were also associated with biomarkers such as serum GGT and uric acid, which are known to be surrogate markers of adverse cardiovascular events and mortality (16,30). This finding is consistent with emerging evidence that increased GGT and uric acid are strongly linked to chronic low-grade inflammation (16,30).…”

Section: Discussionsupporting

confidence: 73%

Gender difference and determinants of C-reactive protein level in Korean adults

Lee

Shin

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (-1.0 mg/L), average-risk (1.0-3.0 mg/L), and high-risk ()3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women. Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007. Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the highrisk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, g-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds

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Section: Discussionsupporting

confidence: 73%

Gender difference and determinants of C-reactive protein level in Korean adults

Lee

Shin

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…UA and Hcy also reflect the overall inflammation based on different mechanisms. In fact, as pointed out by Hayden and Tyagi (30), Hcy and UA are, like CRP and oxidized low-density lipoproteins (LDL), capable of producing injurious stimuli to the endothelium, the arterial vessel wall, and capillaries, causing inflammation and vascular disease (31). In this study we have found that low-grade inflammation is present during the early stage of T2DM.…”

Section: Discussionsupporting

confidence: 63%

Development of multiple complications in type 2 diabetes is associated with the increase of multiple markers of chronic inflammation

Hwang

Chou

et al. 2008

Clinical Laboratory Analysis

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Patients with type 2 diabetes (T2DM) are known at risk for developing cardiovascular disease (CVD), nephropathy, and cancer. We were interested to find out whether multiple markers associated with chronic inflammation are detectable in patients with T2DM and are increased in patients with T2DM who developed additional clinical complications. A sequence of multiple risk markers for atherogenesis, associated with chronic inflammation, was measured in patients with T2DM before and after the development of clinical complications. We found that multiple clinical complications frequently developed simultaneously in patients with T2DM. At the early stage of T2DM, only low levels and low percent elevations of multiple risk markers were detected. However, both the level and the percent elevation of these markers were found to increase with disease progression and the development of clinical complications. We believe that chronic inflammation not only contributes to the pathogenesis of T2DM but also continues to increase in T2DM patients who are developing additional clinical complications. It appears that these multiple markers are potentially useful not only for monitoring the progression of T2DM but also predicting the risk of developing macro-and microvascular disease, nephropathy, and cancer.

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“…The prospective Physicians' Health Study suggested that a high level of CRP would increase the risk of stroke by 2-fold, the risk of myocardial infarction by 3-fold, and the risk of peripheral vascular diseases by 1-fold (Ridker et al, 1997). Increased serum UA levels were reported to be able to promote the development of atherosclerosis (Kanellis and Kang, 2005;Zoccali et al, 2006), and it was reported domestically that UA was an important independent risk factor for type 2 diabetes macroangiopathy. Increased UA might lead to the vascular complications, with the possible reasons as follows: high UA levels would influence traditional factors such as abnormal lipoprotein metabolism and hypertension, and promote the formation of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients

Wang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study aims to investigate the value of highresolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the LEV group (V group) and the nonvasculopathy group (A group). The V group was then divided into the mild (B group), moderate (C group), and severe (D group) subgroups. The relevant clinical parameters were simultaneously recorded. The results showed that the lesion-positive detection rate of HR-CDU was significantly higher than that of clinical examination. The age, disease duration, smoking history, blood pressure, blood sugar, fibrinogen (FIB), C-reactive protein (CRP), uric acid (UA), and urinary albumin excretion (UAE) in the V group were higher than in the N group. In the logistic regression analysis, smoking history, age, disease duration, FIB, UA, and fasting blood glucose were independent risk factors of T2DM LEV. The incidence of LEV in T2DM patients increased significantly with increasing age, UA, FIB, CRP, UAE, disease duration, and smoking history, and the vasculopathy level became more severe. In conclusion, age, disease duration, smoking history, blood pressure, blood sugar, FIB, CRP, UA, and UAE are the related risk factors of LEV in T2DM patients.

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Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease

Cited by 364 publications

References 37 publications

Gender difference and determinants of C-reactive protein level in Korean adults

Gender difference and determinants of C-reactive protein level in Korean adults

Development of multiple complications in type 2 diabetes is associated with the increase of multiple markers of chronic inflammation

High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients

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