Uric acid and bone mineral density in postmenopausal osteoporotic women: the link lies within the fat

Pirro, Matteo; Mannarino, Massimo Raffaele; Bianconi, Vanessa; Vuono, Stefano De; Sahebkar, Amirhosein; Bagaglia, Francesco; Franceschini, Luca; Scarponi, Anna Maria; Mannarino, Elmo; Merriman, Tony R.

doi:10.1007/s00198-016-3792-3

Cited by 22 publications

(22 citation statements)

References 49 publications

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“…Four cross-sectional studies from China reported a positive correlation between a higher sUA and greater BMD among postmenopausal women and older adults [ 19 – 22 ]. This conclusion was supported by other studies from Asia [ 23 – 25 ], as well as from the Netherlands and Italy [ 26 , 27 ]. However, other studies did not support this conclusion.…”

Section: Discussionsupporting

confidence: 80%

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

Yao

Chen

et al. 2020

International Journal of Endocrinology

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Objectives. Uric acid has been found to be potentially protective in bone metabolism. We investigated the relationship between serum uric acid (sUA) and lumbar bone mineral density (BMD) among 4156 participants aged 60 years and over from the National Health and Nutrition Examination Survey (NHANES). Methods. To estimate the association between sUA and lumbar BMD, multivariate logistic regression analyses were conducted. Fitted smoothing curves and generalized additive models were also performed. Results. We found sUA positively correlated with lumbar BMD after adjusting for other confounders. On subgroup analyses, stratified by sex and race/ethnicity, the positive correlation of sUA with lumbar BMD remained in both men and women, as well as in whites and Mexican Americans, but not in blacks. In blacks, the association of sUA with lumbar BMD was an inverted U-shaped curve (inflection point: 7.5 mg/dL). Conclusions. Our study revealed a positive relationship between sUA and lumbar BMD among most old adults. This association followed an inverted U-shaped curve among blacks.

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Section: Discussionsupporting

confidence: 80%

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

Yao

Chen

et al. 2020

International Journal of Endocrinology

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“…However, whether the associations of uric acids with BMD are causal or independent of body fat is unclear yet. [27,[33][34][35] To our best knowledge, our study is the first to report the associations of uric acid precursors, hypoxanthine, and inosine with BMD status, [18][19][20][21][22][23] highlighting the importance of the purine metabolic pathway in bone metabolism.…”

Section: Discussionmentioning

confidence: 65%

Association between the metabolome and bone mineral density in a Chinese population

et al. 2020

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“…Among 32 studies, 21 28 29 30 31 32 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 and 11 23 24 25 26 27 60 61 62 63 64 65 considered VIT D and SUA as the outcome, respectively. Within the 21 studies with VIT D outcome, 6 31 32 44 48 49 50 provided data of SUA and VIT D levels as continuous variables, 14 28 29 30 31 32 45 46 47 49 52 53 54 57 59 assessed association between SUA level as continuous data and categorical VIT D status, while 3 55 56 58 provided categorical data for both.…”

Section: Resultsmentioning

confidence: 99%

“…Most of them(23) were crosssectional studies. Their participants were either from the general population or had specific diseases, with mean age ranging from 36.9 to 76.9 years.Among 32 studies, 21[28][29][30][31][32][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] and 11[23][24][25][26][27][60][61][62][63][64][65] considered VIT D and SUA as the outcome, respectively. Within the 21 studies with VIT D outcome, 6[31,32,44,[48][49][50] provided data of SUA and VIT D levels as continuous variables, 14…”

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confidence: 99%

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

et al. 2020

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Association between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin D and serum uric acid, extracted the data, and conducted analysis by direct and network meta-analysis. The present review included 32 studies, of which 21 had vitamin D as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3 studies of 0.512 (95% confidence interval: 0.199, 0.825) and a significant pooled odds ratio between vitamin D deficiency and hyperuricemia of 1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups with hyperuricemia and normouricemia was non-significant at 0.138 (−0.430, 0.707) ng/ml, and the pooled mean difference of serum uric acid between categories of 25(OH)D were also non-significant at 0.072 (−0.153, 0.298) mg/dl between deficiency and normal, 0.038 (−0.216, 0.292) mg/dl between insufficiency and normal, and 0.034 (−0.216, 0.283) mg/dl between deficiency and insufficiency. In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study.

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Uric acid and bone mineral density in postmenopausal osteoporotic women: the link lies within the fat

Abstract: In postmenopausal osteoporotic women, the strong univariable association between SUA levels and femur BMD is partly explained by the confounding effect of indices of adiposity.

Cited by 22 publications

References 49 publications

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

Association between the metabolome and bone mineral density in a Chinese population

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

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