Uraemic pruritus--new perspectives and insights from recent trials

Mettang, Thomas; Pauli‐Magnus, Christiane; Alscher, Dominik M.

doi:10.1093/ndt/17.9.1558

Cited by 132 publications

(122 citation statements)

References 37 publications

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“…1 It influences 15%-49% of pre-dialysis CKD patients and 50%-90% of those on dialysis including peritoneal dialysis and hemodialysis (HD). 2 Intensity and distribution of CKD-aP changed markedly over time.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Panahi¹,

Dashti‐Khavidaki²,

Farnood³

et al. 2016

Adv Pharm Bull

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Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Panahi¹,

Dashti‐Khavidaki²,

Farnood³

et al. 2016

Adv Pharm Bull

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“…Multiple factors have been suggested to play a role in the occurrence of UP, including xerosis, hyperphosphatemia, hyperphosphaetemia, secondary hyperparathyroidism, the stimulation of opioid receptors, iron deficiency anemia, the proliferation of histaminesecreting skin mast cells, and generalized inflammation (7)(8)(9). Immunohypothesis is currently favored as an explanation of the cause of UP (10). Some studies have suggested that UP is related to the involvement of immune system with the derangement of T helper (Th) cells differentiation (more have nominated Th1 differentiation as the responsible parameter) (11).…”

Section: Introductionmentioning

confidence: 99%

“…Immunohypothesis is currently favored as an explanation of the cause of UP (10). Some studies have suggested that UP is related to the involvement of immune system with the derangement of T helper (Th) cells differentiation (more have nominated Th1 differentiation as the responsible parameter) (11).…”

Section: Introductionmentioning

confidence: 99%

Effects of Fumaria parviflora L on Uremic Pruritus in Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Akrami

Hashempur

Tavakoli

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Uremic pruritus (UP) is a common, bothersome symptom in hemodialysis (HD) patients with end-stage renal disease. Immunohypothesis is currently favored as an explanation of the cause of UP. Fumaria parviflora L (FP) is a medicinal herb with several pharmacological properties, including prominent anti-inflammatory activity. Objectives: This study aimed to assess the efficacy of FP for reducing UP severity among HD patients. Methods: A total of 79 HD patients with pruritus were randomly assigned to receive either FP or a placebo for eight weeks. The visual analogue scale (VAS), the Duo score for calculating pruritus score, serum interferon-γ (IFN-γ) level, interleukin-4 (IL-4), and high-sensitivity C-reactive protein were measured in the patients before and after treatment. Results: At the end of the treatment phase, the pruritus score decreased in both groups (P < 0.001); however, the mean reduction

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“…The symptom that most frequently affects these patients is pruritus, [2][3][4][5][6][7][8][9][10][11][12] ranging between 22% and 90% in prevalence. [1][2][3][4][6][7][8][9][13][14][15] It often begins six months before the start of dialysis and manifests itself in markedly different ways; it may be persistent, intense and widespread or just localized and transient. 4.14 Pruritus causes changes in quality of life and 11 has a physical and mental impact, which contribute to depression, agitation, sleep disturbances and fatigue.…”

Section: Introductionmentioning

confidence: 99%

Avaliação da associação entre as alterações no metabolismo mineral e o prurido nos pacientes em hemodiálise

Welter

Frainer

Maldotti

et al. 2011

An. Bras. Dermatol.

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FUNDAMENTOS: prurido é o sintoma mais freqüente nos pacientes nefropatas em hemodiálise. Parâmetros laboratoriais anormais têm sido encontrados, com dados conflitantes. OBJETIVO: relacionar a prevalência de prurido com alterações no metabolismo mineral de pacientes em hemodiálise. MÉTODOS: estudo caso-controle. Avaliados 105 pacientes, sendo os pacientes com prurido os casos, preencheram o questionário do protocolo de pesquisa e a escala análoga visual, os dados laboratoriais foram coletados dos prontuários eletrônicos. RESULTADOS: a média de idade foi de 51,9 anos, 59% dos pacientes eram homens e 43% dos pacientes tinham prurido. Xerodermia ocorreu em 45% dos pacientes. Níveis elevados de Ca foram demonstrados em 55% dos pacientes e 47% tinham prurido. Quanto ao fósforo 60% tinham valores elevados e 43% tinham prurido. A relação Ca/P foi normal em todos. O paratormônio mostrou-se elevado em 95% dos pacientes, todos referindo prurido. CONCLUSÃO: houve associação estatisticamente significativa entre o grupo de pacientes com prurido e xerodermia. Os níveis séricos de Cálcio, Fósforo, relação Ca/P, PTHi e o tamanho do dialisador não apresentaram associação estatisticamente significativa com o prurido. Logo, encontramos relação importante entre xerodermia e prurido, sem relação com os parâmetros laboratoriais avaliados.

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Uraemic pruritus--new perspectives and insights from recent trials

Cited by 132 publications

References 37 publications

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Effects of Fumaria parviflora L on Uremic Pruritus in Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Avaliação da associação entre as alterações no metabolismo mineral e o prurido nos pacientes em hemodiálise

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