2004
DOI: 10.1007/s00280-004-0861-7 View full text |Buy / Rent full text
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Abstract: THP is partially taken up into M5076 cells via a novel Na+-dependent transport system common to nucleosides.

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“…Although CNT3 has also been described as being present along the rat nephron (Rodriguez‐Mulero et al 2005), little is currently known about its function in the uptake/reuptake of nucleoside‐derived drugs. CNT3 is a concentrative nucleoside carrier with a wide substrate selectivity, accepting both purines and pyrimidines (Ritzel et al 2001), and its role in drug transport is mostly unknown (Mangravite et al 2003), being involved in the uptake of araC (Sarkar et al 2005), and other non‐nucleosidic drugs, such as the anthraycline pirarubicine (Nagai et al 2005).…”
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“…Although CNT3 has also been described as being present along the rat nephron (Rodriguez‐Mulero et al 2005), little is currently known about its function in the uptake/reuptake of nucleoside‐derived drugs. CNT3 is a concentrative nucleoside carrier with a wide substrate selectivity, accepting both purines and pyrimidines (Ritzel et al 2001), and its role in drug transport is mostly unknown (Mangravite et al 2003), being involved in the uptake of araC (Sarkar et al 2005), and other non‐nucleosidic drugs, such as the anthraycline pirarubicine (Nagai et al 2005).…”
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“…It shows wide substrate selectivity, accepting both purine and pyrimidine nucleosides, and has a 2:1 Na ϩ /nucleoside coupling ratio, allowing it to concentrate nucleosides intracellularly 10 times more efficiently than CNT1 or CNT2, which show a 1:1 Na ϩ /nucleoside stoichiometry (Ritzel et al, 2001). Its role in drug transport is not well known, being involved in the uptake of cladribine and fludarabine (Mangravite et al, 2003) and of cytosine arabinoside (Sarkar et al, 2005), as well as other non-nucleosidic drugs, such as the anthracycline pirarubicin (Nagai et al, 2005). CNT3 has also been shown to transport gemcitabine and the antiviral drugs azidothymidine and ribavirin (Hu et al, 2006;Yamamoto et al, 2007).…”
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“…Известно несколько лекарственных препаратов, субстратов нуклеозидных транспортеров. Например, противоопухолевый препарат гемцитабин и противовирусный препарат зидовудин (AZT) являются субстратами натрий-зависимых нуклеозидных транспортеров [32,33].…”
Section: природа гематоэнцефалического барьера (гэб) (строение функции)unclassified