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Cited by 183 publications
(113 citation statements)
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References 32 publications
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“…Uptake of MMA(III) (1 μM) by rat hepatocytes was approximately 50% of the total arsenic, while uptake of MMA(V) (1 μM) was considerably lower (Styblo et al, 2000). Uptake of MMA(III) was also greater than that of MMA(V) by Chinese hamster ovary cells (Dopp et al, 2004). The reason for this difference in hepatic uptake of these two arsenicals is not known.…”
Section: Discussionmentioning
confidence: 93%
“…Uptake of MMA(III) (1 μM) by rat hepatocytes was approximately 50% of the total arsenic, while uptake of MMA(V) (1 μM) was considerably lower (Styblo et al, 2000). Uptake of MMA(III) was also greater than that of MMA(V) by Chinese hamster ovary cells (Dopp et al, 2004). The reason for this difference in hepatic uptake of these two arsenicals is not known.…”
Section: Discussionmentioning
confidence: 93%
“…Especially the trivalent arsenicals are known to exhibit strong genotoxic effects (Dopp et al, 2010a). These effects can either be detected as DNA damage using the micronucleus test or the comet assay (Dopp et al, 2008), as oxidative damage by assaying the amount of 8-oxo-dG (8-Oxo-2'-deoxyguanosine) or in form of chromosomal aberrations (Dopp et al, 2004). In our study we determined the Alkaline Comet Assay to analyse single and double strand breaks of the DNA.…”
Section: Discussionmentioning
confidence: 99%
“…For example, Kligerman et al (14) suggested that methylation of the trivalent forms of arsenic increased their genotoxicity and cytotoxicity. Compared with iAs 3ϩ , methylated trivalent arsenicals, such as MMA 3ϩ and DMA 3ϩ , were found to be more potent in causing DNA strand breaks in human lymphocytes and to induce a greater extent of cytotoxic and genotoxic effects, such as micronucleus formation, chromosome aberrations, and sister chromatid exchange (15,16). A better understanding of the biotransformation metabolism of arsenic should shed light on the relationship between arsenic and its related diseases (17,18).…”
Section: ؉ ) To Give Monomethylarsonic Dicysteine (Madc 3؉mentioning
confidence: 99%