Uptake of 2-[18F]fluoro-2-deoxy-D-glucose in uterine leiomyoma: imaging of four patients by coincidence positron emission tomography

Ak, İlknur; Özalp, Sinan; Yalçın, Ömer; Zor, E.; Vardareli̇, Erkan

doi:10.1097/00006231-200409000-00012

Cited by 39 publications

(16 citation statements)

References 22 publications

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“…In general, SUV values for leiomyosarcoma were observed to be significantly greater than those for leiomyoma. However, numerous reports for 18-FDG-avid leiomyoma were also identified (36)(37)(38). Furthermore, a series of comprehensive analyses for those patients who underwent 18-FDG-PET/CT revealed that small proportion of benign uterine leiomyomas exhibited positive 18-FDG uptake.…”

Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review

et al. 2017

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Abstract. Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease entity that usually occurs in females of reproductive age with a previous history of uterine myoma. It is typically characterized by multiple pulmonary tumors consisting of benign leiomyoma cells. In the present study, two cases of PBML are discussed. The patient in each case underwent 2-deoxy-2-(fluorine-18)-fluoro-D-glu cose positron emission tomography/computed tomography (18-FDG-PET/CT) scans. One patient demonstrated a lack of 18-FDG uptake and a quiescent clinical course. However, the second patient exhibited a markedly high uptake of 18-FDG and aggressive cell proliferation. The two tumors revealed significant differences in metabolic behavior and in clinical course; however, they were similar with regard to cellular appearance. A review of previous studies concerning the findings of 18-FDG-PET/CT in published cases of PBML was also conducted and is presented here.

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Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review

et al. 2017

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“…However, there have been several reports of PET-positive leiomyomas [22][23][24]. Absent FDG-PET avidity was a preoperative sign that this was a benign tumor, especially as a heterogeneous adrenal tumor on CT imaging is likely to be a high-grade carcinoma that would be expected to be FDG-PET positive [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Leiomyoma of the Adrenal Gland Presenting as a Non-Functioning Adrenal Incidentaloma: Case Report and Review of the Literature

Wasco

Korobkin

et al. 2007

Endocr Pathol

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A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneous mass that was not FDG avid. Because of concern for adrenal cortical carcinoma, the patient underwent a successful right adrenalectomy. Pathology examination demonstrated an 11-cm circumscribed mass consisting of uniform spindle cells without nuclear pleomorphism, necrosis, or mitotic activity. The diagnosis of leiomyoma was supported by a panel of immunohistochemical stains. Adrenal leiomyomas have been reported in the literature, although most are small and not preoperatively suspicious for malignancy. This case illustrates that benign tumors such as leiomyomas, when large and heterogeneous on imaging, can clinically mimic adrenal cortical carcinomas and should be included in the differential diagnosis of adrenal incidentalomas.

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“…In addition, FDG uptake in uterine leiomyoma declines with age [37]. But there are some case reports of intense FDG uptake in large or degenerated benign leiomyomas [36,[38][39][40][41]. Reported high uptake in the leiomyomas might be owing to increased vascularity [40] or large sizes of the tumors [41].…”

Section: Endometrial Uptakementioning

confidence: 99%

“…Reported high uptake in the leiomyomas might be owing to increased vascularity [40] or large sizes of the tumors [41]. In addition, high levels of growth factors and receptors related to proliferation of smooth muscle may play a role in FDG accumulation [38]. Therefore, nonmenstrual-related endometrial uptake may represent either benign or malignant process.…”

Section: Endometrial Uptakementioning

confidence: 99%

Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

Liu

2009

Ann Nucl Med

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Increased ovarian or endometrial uptake may cause a dilemma in the interpretation of whole body F18-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging or even misdiagnosis of malignant disease. Knowledge of benign FDG uptake of the ovaries and uterus is important for daily practice of nuclear medicine radiologists. Increased uptake in the ovaries or uterus indicates a pathologic or neoplastic process in postmenopausal patients. In premenopausal women, increased ovarian or endometrial uptake can be functional or malignant. Benign functional uptake of premenopausal ovaries or uterus is related to the menstrual cycle; therefore, information about the patient's menstrual status is crucial for interpretation. In addition, correlation with computed tomography (CT), especially diagnostic CT acquired at the same time of PET/CT is very useful in clarifying the location of the uptake and the existence or disappearance of the discrete lesion. Increased ovarian uptake may also be identified in histologically different benign tumor entities. Nonmenstrual-related endometrial uptake may be present in many benign diseases as well.

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Uptake of 2-[18F]fluoro-2-deoxy-D-glucose in uterine leiomyoma: imaging of four patients by coincidence positron emission tomography

Cited by 39 publications

References 22 publications

Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review

Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review

Leiomyoma of the Adrenal Gland Presenting as a Non-Functioning Adrenal Incidentaloma: Case Report and Review of the Literature

Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

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