Uptake and toxic effects of triphenyl phosphate on freshwater microalgae Chlorella vulgaris and Scenedesmus obliquus: Insights from untargeted metabolomics

Wang, Lei; Huang, Xulei; Lim, Dorothy Jingwen; Laserna, Anna Karen Carrasco; Li, Sam Fong Yau

doi:10.1016/j.scitotenv.2018.09.024

Cited by 49 publications

(17 citation statements)

References 54 publications

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“…Environmental toxicity assessment protocols for the selection of environmentally safe compounds are well-established for the microalgae Chlorella vulgaris and Scenedesmus obliquus [86][87][88][89] and for the ciliated protozoan T. pyriformis. 46,90 The compounds 3a, 3e, 6a, 6c, 6d and 6f were not toxic to the algae Chlorella vulgaris BR017 and to the protozoan T. pyriformis, indicating that they are relatively safe for the environment.…”

Section: Discussionmentioning

confidence: 99%

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Targanski

Sousa

Pádua

et al. 2020

Pest Management Science

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BACKGROUND: The expansion of Aedes aegypti (Diptera: Culicidae) population has increased the number of cases of arboviruses, in part due to the inefficiency and toxicity of the chemical control methods available to control this vector. We synthesized 19 chalcone derivatives and examined their activity against Ae. aegypti larvae in order to select larvicidal compounds that are non-toxic to other organisms. RESULTS: Seven chalcone derivatives (3a, 3e, 3f, 6a, 6c, 6d, and 6f) had lethal concentrations of substituted chalcones capable of killing 50% (LC 50) values lower than 100 mg mL −1 at 24 h post-treatment, which is the dose that the World Health Organization recommends for the selection of promising larvicides. The type of substituent added to (E)-1,3-diphenylprop-2-en-1-one (3a) markedly affected the larvicidal activity. Addition of chlorine, bromine and methoxy groups to the aromatic rings reduced the larvicidal activity, while replacement of the Bring (phenyl) by a furan ring significantly increased the larvicidal activity. The furan-chalcone (E)-3-(4-bromophenyl)-1-(furan-2-yl)prop-2-en-1-one (6c) killed Ae. aegypti larvae (LC 50 = 6.66 mg mL −1 ; LC 90 = 9.97 mg mL −1) more effectively than the non-substituted chalcone (3a) (LC 50 = 14.43 mg mL −1 ; LC 90 = 20.96 mg mL −1), and was not toxic to the insect Galleria mellonella, to the protozoan Tetrahymena pyriformis, and to the algae Chorella vulgaris. CONCLUSIONS: The substitution pattern of chalcones influenced their larvicidal activity. In the set of compounds tested, (E)-3-(4-bromophenyl)-1-(furan-2-yl)prop-2-en-1-one (6c) was the most effective larvicide against Ae. aegypti, with no clear signs of toxicity to other animal models. Its mechanism of action and effectiveness under field conditions remain to be determined.

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Section: Discussionmentioning

confidence: 99%

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Targanski

Sousa

Pádua

et al. 2020

Pest Management Science

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“…A metabolic profiling technique was developed for the model green microalga, Chlamydomonas reinhardtii , under stress conditions such as nitrogen-, phosphorus-, sulfur- and iron-depletion ( Bölling and Fiehn, 2005 ). A method to assess the metabolism of freshwater microalga C. vulgaris and Scenedesmus obliquus after being exposed to the flame retardant triphenyl phosphate was also recently established ( Wang et al, 2019 ). Furthermore, potential biomarkers of C. reinhardtii grown in photobioreactors in the context of nitrogen starvation were found using metabolomics ( Courant et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Global Metabolomics Reveals That Vibrio natriegens Enhances the Growth and Paramylon Synthesis of Euglena gracilis

Ouyang

Chen

Zhao

et al. 2021

Front. Bioeng. Biotechnol.

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The microalga Euglena gracilis is utilized in the food, medicinal, and supplement industries. However, its mass production is currently limited by its low production efficiency and high risk of microbial contamination. In this study, physiological and biochemical parameters of E. gracilis co-cultivated with the bacteria Vibrio natriegens were investigated. A previous study reports the benefits of E. gracilis and V. natriegens co-cultivation; however, no bacterium growth and molecular mechanisms were further investigated. Our results show that this co-cultivation positively increased total chlorophyll, microalgal growth, dry weight, and storage sugar paramylon content of E. gracilis compared to the pure culture without V. natriegens. This analysis represents the first comprehensive metabolomic study of microalgae-bacterial co-cultivation, with 339 metabolites identified. This co-cultivation system was shown to have synergistic metabolic interactions between microalgal and bacterial cells, with a significant increase in methyl carbamate, ectoine, choline, methyl N-methylanthranilate, gentiatibetine, 4R-aminopentanoic acid, and glu-val compared to the cultivation of E. gracilis alone. Taken together, these results fill significant gaps in the current understanding of microalgae-bacteria co-cultivation systems and provide novel insights into potential improvements for mass production and industrial applications of E. gracilis.

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“…Through the characterization of the metabolites obtained from the environment, paleometabolites (diagenetic products of chlorophylls and carotenoids derived from photosynthetic algae and bacteria) can be identified [138]. In addition, this technique can be used to determine the toxic effects of organophosphates on the species in freshwater ecosystems [139]. The above compilation is an example of the increasing research areas where chlorophyll and carotenoid metabolomics are involved.…”

Section: Application In Abiotic Factors Studiesmentioning

confidence: 99%

Metabolomics of Chlorophylls and Carotenoids: Analytical Methods and Metabolome-Based Studies

Roca

Pérez‐Gálvez

2021

Antioxidants

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Chlorophylls and carotenoids are two families of antioxidants present in daily ingested foods, whose recognition as added-value ingredients runs in parallel with the increasing number of demonstrated functional properties. Both groups include a complex and vast number of compounds, and extraction and analysis methods evolved recently to a modern protocol. New methodologies are more potent, precise, and accurate, but their application requires a better understanding of the technical and biological context. Therefore, the present review compiles the basic knowledge and recent advances of the metabolomics of chlorophylls and carotenoids, including the interrelation with the primary metabolism. The study includes material preparation and extraction protocols, the instrumental techniques for the acquisition of spectroscopic and spectrometric properties, the workflows and software tools for data pre-processing and analysis, and the application of mass spectrometry to pigment metabolomics. In addition, the review encompasses a critical description of studies where metabolomics analyses of chlorophylls and carotenoids were developed as an approach to analyzing the effects of biotic and abiotic stressors on living organisms.

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Uptake and toxic effects of triphenyl phosphate on freshwater microalgae Chlorella vulgaris and Scenedesmus obliquus: Insights from untargeted metabolomics

Cited by 49 publications

References 54 publications

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Global Metabolomics Reveals That Vibrio natriegens Enhances the Growth and Paramylon Synthesis of Euglena gracilis

Metabolomics of Chlorophylls and Carotenoids: Analytical Methods and Metabolome-Based Studies

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