2020
DOI: 10.1111/jgh.15150
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Abstract: Background and AimTubulointerstitial nephritis antigen‐like 1 (TINAGL1), as a novel matricellular protein, has been demonstrated to participate in cancer progression, whereas the potential function of TINAGL1 in gastric cancer (GC) remains unknown.MethodsThe expression pattern of TINAGL1 in GC was examined by immunohistochemistry, ELISA, real‐time polymerase chain reaction, and Western blot. Correlation between TINAGL1 and matrix metalloproteinases (MMPs) was analyzed by the GEPIA website and Kaplan–Meier plot… Show more

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Cited by 11 publications
(7 citation statements)
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“…MMP9 plays a crucial role in the degradation of the ECM (32)(33)(34). Moreover, the upregulation of MMP9 was related to metastasis in GC (35,36). Thus, our experiments confirmed that lncRNA GRASLND was the potential contributor towards regulation of ECM.…”
Section: Discussionsupporting
confidence: 75%
“…MMP9 plays a crucial role in the degradation of the ECM (32)(33)(34). Moreover, the upregulation of MMP9 was related to metastasis in GC (35,36). Thus, our experiments confirmed that lncRNA GRASLND was the potential contributor towards regulation of ECM.…”
Section: Discussionsupporting
confidence: 75%
“…Currently, multiple biological functions of matricellular proteins have been found (including activation cellular signaling, and regulation of cell adhesion, differentiation, proliferation and migration), and studies have shown that matricellular proteins play an important role in multiple diseases 24 . At present, except for tumors, little is still known about the function of TINAGL1 in other diseases 22,25‐28 . Here, we found that the expression of TINAGL1 is decreased in diabetic wound tissues, and topical application of TINAGL1 promotes wound healing in diabetic mice by promoting granulation tissue formation.…”
Section: Discussionmentioning
confidence: 79%
“…24 At present, except for tumors, little is still known about the function of TINAGL1 in other diseases. 22,[25][26][27][28] Here, we found that the expression of TINAGL1 is decreased in diabetic wound tissues, and topical application of TINAGL1 promotes wound healing in diabetic mice by promoting granulation tissue formation. In the granulation tissue formation stage, the collagens are deposited and neovascularization, 29 and fibroblasts play an important role in this stage.…”
Section: Discussionmentioning
confidence: 99%
“…However, it is important to note that Tinagl1 plays a complicated role in cancer. Recent work in gastric and hepatic cancer has found that Tinagl1 expression is actually associated with cancer progression through the upregulation of VEGF and matrix metallopeptidases, which leads to metastasis. , These conflicting findings do not, however, undermine the potential benefits of Tinagl1; rather, they highlight the profound differences across cancer subtypes and the need to fully characterize both the disease state and Tinagl1’s role more deeply. In TNBC models, we see an increase in VEGF, but the growth suppression and reduction in Hif1α seem to outweigh the risks that VEGF expression typically raises in cancer therapy.…”
Section: Discussionmentioning
confidence: 99%