Upregulation of Long Noncoding RNA FGD5-AS1 Ameliorates Myocardial Ischemia/Reperfusion Injury via MicroRNA-106a-5p and MicroRNA-106b-5p

Hao, Lin; Wang, Juan; Bi, Shao‐Jie; Cheng, Chao

doi:10.1097/fjc.0000000000001036

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…Interestingly, SNHG3, TUG1, GAS5, and SCARNA9 were identi ed as immune-related lncRNAs in different cancers [44][45][46][47]. Besides, the antiapoptotic effect of SNHG3, LINC00152, TUG1, and FGD5-AS1has been validated in different cancer cell models [43,[48][49][50]. Nevertheless, their immunological and apoptotic roles in the progression of HSPN in children have not been explored to date.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in Henoch-Schönlein purpura nephritis of children

Huang

Xie

et al. 2022

Preprint

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Long noncoding RNAs (lncRNAs) play important roles in the regulation of immunological and apoptotic function. Here, we aimed to explore critical immune- and apoptosis-related lncRNAs in the occurrence and development of Henoch-Schönlein purpura nephritis (HSPN) in children. Through differentially expressed analysis, we identified differentially expressed lncRNAs, immune- and apoptosis-related mRNAs in the peripheral blood samples of children with HSPN. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses validated the immunological and apoptotic roles of the differentially expressed immune-related and apoptosis-related mRNAs. Following, we analyzed the correlations of differentially expressed lncRNAs and immune- and apoptosis-related mRNAs by Spearman’s correlation analysis, and determined 100 critical immune- and apoptosis-related lncRNAs in HSPN of children. Based on competing endogenous RNAs (ceRNA) mechanism, we constructed the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in HSPN of children, and validated the expression levels of lncRNAs in the lncRNA-miRNA-mRNA regulatory network. Collectively, we proposed that the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network might participate in the modulation of pathogenesis of HSPN in children. In addition, the lncRNAs in the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network (upregulated SNHG3, LINC00152, TUG1, GAS5, FGD5-AS1, DLEU2, and SCARNA9; downregulated SNHG1, NEAT1, DISC1-IT1, and PVT1) could become novel biomarkers for the diagnosis of HNSP in children.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in Henoch-Schönlein purpura nephritis of children

Huang

Xie

et al. 2022

Preprint

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show abstract

“…Studies thus far have mainly focused on the roles of these lncRNAs in regulating the occurrence and development of various cancers (40,41). SNHG3, TUG1, GAS5, and SCARNA9 have been identified as immune-related lncRNAs in different cancers (42)(43)(44)(45), and the anti-apoptotic effects of SNHG3, LINC00152, TUG1, and FGD5-AS1 have been validated in different cancer cell models (41,(46)(47)(48). Nevertheless, to date, their immunological and apoptotic roles in the progression of HSPN in children have not been explored.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in children with Henoch Schönlein purpura nephritis

Huang¹,

Li²,

Wang³

et al. 2022

Transl Pediatr

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Background Long noncoding RNAs (lncRNAs) play important roles in the regulation of immunological and apoptotic function. This study aimed to explore the critical immune- and apoptosis-related lncRNAs in the occurrence and development of Henoch-Schönlein purpura nephritis (HSPN) in children. Methods Differential analysis was employed to identify the differentially expressed lncRNAs, as well as the immune- and apoptosis-related mRNAs in children with HSPN. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to validate the immunological and apoptotic roles of the differentially expressed immune- and apoptosis-related lncRNAs and mRNAs. Spearman’s correlation analysis was performed to analyze the differentially expressed lncRNAs and immune- and apoptosis-related messenger RNAs (mRNAs). Based on the competing endogenous RNA (ceRNA) mechanism, the immune- and apoptosis-related lncRNA-microRNA (miRNA)-mRNA regulatory network was then constructed in children with HSPN. The expression levels of the lncRNAs in the lncRNA-miRNA-mRNA regulatory network were further confirmed by quantitative real-time polymerase chain in the peripheral blood samples of children with HSPN. Results By intersecting the differentially expressed immune-related and apoptosis-related genes through GO and KEGG analyses, a total of 43 genes were identified in children with HSPN, and 100 lncRNAs highly correlated with the above genes were identified by correlation analysis. The immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network was then established based on ceRNA mechanism. Dysregulation of a total of 11 lncRNAs were discovered, including upregulated SNHG3, LINC00152, TUG1, GAS5, FGD5-AS1, DLEU2, and SCARNA9; and downregulated SNHG1, NEAT1, DISC1-IT1, and PVT1. The validation conducted in the clinical samples also suggested that the above lncRNAs in the specific regulatory network may act as potential biomarkers with prognosis in children with HSPN. Conclusions LncRNAs may play essential regulatory roles in the occurrence and development of HSPN in children, and the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network might be the underlying molecular mechanism that dissects the disease pathogenesis. In addition, the dysregulated lncRNAs in the regulatory network may be novel biomarkers for the diagnosis and therapy of HSPN in children.

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“…Serum miR-30d levels are markedly reduced in AHF patients and can be used to predict survival in AHF patients [ 17 ]. miR-106a-5p is closely associated with diverse cardiovascular diseases such as myocardial ischemia/reperfusion injury and coronary artery disease [ 18 , 19 ]. It is also a promising marker for acute myocardial infarction [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of plasma miR-106a-5p levels in patients with acute heart failure

Fei,

Li,

et al. 2024

J Cardiothorac Surg

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Background It is essential to find reliable biomarkers for early diagnosis and prognosis of acute heart failure (AHF) for its mitigation. Currently, increasing attention is paid to the role of microRNAs (miRNAs/miRs) as diagnostic or prognostic markers for cardiovascular diseases. Since plasma miR-106a-5p has been observed to be downregulated in AHF, its value in the diagnosis and prognostic assessment of AHF deserves further exploration. Accordingly, this study analyzed the diagnostic and prognostic value of plasma miR-106a-5p in AHF patients. Methods Prospectively, this study included 127 AHF patients who met the 2021 European Society of Cardiology Guidelines and 127 control individuals. Plasma miR-106a-5p levels were determined with RT-qPCR. Spearman correlation analysis was performed to evaluate the correlation of plasma miR-106a-5p levels with NT-proBNP and hs-CRP levels in AHF patients. All AHF patients were followed up for 1 year and allocated into poor and good prognosis groups, and plasma miR-106a-5p levels were compared. The diagnostic and prognostic value of plasma miR-106a-5p for AHF was assessed with a receiver-operating characteristic curve. Results Plasma miR-106a-5p was lowly expressed in AHF patients versus controls (0.53 ± 0.26 vs. 1.09 ± 0.46) and showed significant negative correlations with NT-proBNP and hs-CRP levels. Plasma miR-106a-5p level < 0.655 could assist in AHF diagnosis. Plasma miR-106a-5p levels were markedly lower in poor-prognosis AHF patients than in good-prognosis patients. Plasma miR-106a-5p level < 0.544 could assist in predicting poor prognosis in AHF patients. Conclusion Plasma miR-106a-5p is downregulated in AHF patients and could assist in diagnosis and poor prognosis prediction of AHF.

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Upregulation of Long Noncoding RNA FGD5-AS1 Ameliorates Myocardial Ischemia/Reperfusion Injury via MicroRNA-106a-5p and MicroRNA-106b-5p

Cited by 12 publications

References 38 publications

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in Henoch-Schönlein purpura nephritis of children

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in Henoch-Schönlein purpura nephritis of children

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in children with Henoch Schönlein purpura nephritis

Diagnostic and prognostic value of plasma miR-106a-5p levels in patients with acute heart failure

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