Upper Gastrointestinal Endoscopic Biopsy; Morphological Spectrum of Lesions

Abstract

… Background: Upper GI endoscopy is an established procedure for investigating a wide range of upper GI conditions especially inflammatory and malignant diseases of stomach and esophagus. A good correlation in diagnosis can be achieved by complementing endoscopic findings with histology of biopsy specimens. Aims and objectives: 1) To evaluate morphological patterns of upper GI conditions. 2) To correlate endoscopic characterization of upper GI lesions with histopathological assessment of biopsy specimens. Study design: A retrospective descriptive study. Period: Four year period from January 2010 to December 2013. Setting: Department of Pathology, LUMHS and were histologically assessed. Material and methods: A total of 433 upper GI endoscopic biopsies were received. Patient's age, gender and presenting complaints were noted. Results: Stomach was the most frequent site of endoscopic biopsy (51.3%) followed by esophagus (39%) and duodenum (9.7%). Majority of patients (51%) presented with dysphagia and abdominal pain. Mean age of presentation was 40 years; age range, 9-90 years and male: female ratio is 1:1.6. Esophageal malignancy was the commonest neoplastic lesion with squamous cell carcinoma being the dominant histological type. Interestingly, inflammatory conditions were more common in the stomach. In the duodenum, celiac disease was clinically suspected and histopathological grading confirmed the diagnosis with majority of the cases showing grade-II pathology. Conclusion: This large retrospective institutional based study showed a good correlation between endoscopic and histological diagnosis. It further shows that esophagus is the predominant site of upper GI malignancy with strong female predominance. Further studies are needed to identify the underlying risk factors. Article Citation: Memon F, Baloch K, Memon AA. Upper gastrointestinal endoscopic biopsy; morphological spectrum of lesions. Professional Med J 2015;22(12):1574-1579.

Histopathological Spectrum of Non-Malignant Lesions of Gastrointestinal Tract- An Institutional Study.

“…In proved cases, any sign of dysplasia especially high grade dysplasia, advocates colectomy as the next immediate intervention. [10] Gastritis can be classified into chronic superficial, chronic nonspecific, erosive gastritis, gastritis with intestinal metaplasia and H. pylori positive gastritis. We came across 02 (1.01%) cases of chronic nonspecific gastritis.…”

“…[10] We had only 02 cases of acute and acute on chronic inflammation of the duodenum. Neil A Shepherd et al, showed considerable non-neoplastic lesions affecting the duodenum.…”

Histomorphology Of Upper GI Endoscpic Biopsies: A Study In Urban Care Centre

“…In our study the incidence of dysplasia of the oesophagus was 0.8% and it was 4.1% in Memon F, et al's study group 13 . Dysplasia of the oesophagus either progress from low grade to high grade or regress.Waf1p21 reactivity decreases in the dysplastic epithelium whereas immuno reactivity for PCNA and P53 increase 14 . In our study 65.57% of the cases had squamous cell carcinoma which was in consistent with Memon F, et al's study [78.6%] 13 …”

Distance Based Energy Optimization through Improved Fitness Function of Genetic Algorithm in Wireless Sensor Network

“…This operator opted for the selection of all strong individuals corresponding on the basis of fitness values (Memon et al, 2015). All population have a certain value of fitness level.…”

“…The majority has been done using optimization for the sake of minimum energy consumption (Memon et al, 2015). Hence, the optimization is an efficient method for optimizing both the route and energy of the sensor node and WSNs.…”