Upper Airway Changes After Mandibular Setback and/or Advancement Genioplasty in Obese Patients

Du, Wen; He, Dedong; Wang, Yiyao; Liu, Hanghang; Liao, Chuhang; Wei, Fei; Luo, En

doi:10.1016/j.joms.2017.04.012

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…The outcomes of this study are consistent with the results of several investigations that reported significant constriction of the pharyngeal airway after treatment of mandibular prognathism [5][6][7]23]. Other studies reported worsening of sleep quality or the occurrence of sleep apnea after mandibular setback surgery in subjects with no signs or symptoms of airway obstruction before the operation [24,25].…”

Section: T1-t0supporting

confidence: 90%

“…Numerous studies investigated the impact of orthognathic procedures on the pharyngeal airway space in patients with class III abnormality. Although the majority of studies demonstrated a significant reduction in airway volume after single-jaw mandibular setback surgery [1,3,6,7], there are controversial reports about the effect of bimaxillary surgery [5,[8][9][10][11][12] with some studies indicating an increase [10] and others exhibiting decrease [4,9,12,13] or maintenance [11,[14][15][16] of airway volume following a combination of maxillary advancement and mandibular setback surgery. Furthermore, most studies included small sample sizes and focused on one or two groups of patients that underwent mandibular setback or bimaxillary surgery for correction of class III dysplasia, whereas the effect of maxillary advancement on airway space has not been sufficiently compared with the two other surgical modalities at the same settings.…”

Section: Open Accessmentioning

confidence: 99%

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Changes in the pharyngeal airway after different orthognathic procedures for correction of class III dysplasia

Khaghaninejad

Khojastehpour

Danesteh

et al. 2022

Maxillofac Plast Reconstr Surg

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Objective This study was conducted to compare changes in pharyngeal airway after different orthognathic procedures in subjects with class III deformity. Methods The study included CBCT scans of 48 skeletal class III patients (29 females and 19 males, mean age 23.50 years) who underwent orthognathic surgery in conjunction with orthodontic treatment. The participants were divided into three groups of 16, as follows: Group 1, mandibular setback surgery; group 2, combined mandibular setback and maxillary advancement surgery; and group 3, maxillary advancement surgery. CBCT images were taken 1 day before surgery (T0), 1 day (T1), and 6 months (T2) later. The dimensions of the velopharynx, oropharynx, and hypopharynx were measured in CBCT images. Results In all groups, there was a significant decrease in airway variables immediately after surgery, with a significant reversal 6 months later (P < 0.05). In subjects who underwent maxillary advancement, the airway dimensions were significantly greater at T2 than the T0 time point (P < 0.05), whereas in the mandibular setback and bimaxillary surgery groups, the T2 values were lower than the baseline examination (P < 0.05). The alterations in airway variables were significantly different between the study groups (P < 0.05). Conclusions The mandibular setback procedure caused the greatest reduction in the pharyngeal airway, followed by the bimaxillary surgery and maxillary advancement groups, with the latter exhibiting an actual increase in the pharyngeal airway dimensions. It is recommended to prefer a two-jaw operation instead of a mandibular setback alone for correction of the prognathic mandible in subjects with predisposing factors to the development of sleep-disordered breathing.

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Section: T1-t0supporting

confidence: 90%

Section: Open Accessmentioning

confidence: 99%

Changes in the pharyngeal airway after different orthognathic procedures for correction of class III dysplasia

Khaghaninejad

Khojastehpour

Danesteh

et al. 2022

Maxillofac Plast Reconstr Surg

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“…M values are logit transformation of the beta values, which is M = log (beta/1-beta). M values were used as outcome variables for subsequent analysis because they have been shown to have better statistical properties such as homoscedasticity ( Du et al, 2017 ). For the analysis of individual CpGs, an absolute delta beta > 0.30 was used to detect differential methylation between twins.…”

Section: Methodsmentioning

confidence: 99%

DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Non-syndromic Cleft Lip and Palate

Young

Slifer

Hecht

et al. 2021

Front. Cell Dev. Biol.

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Non-syndromic cleft lip with or without cleft palate (NSCLP) is the most common craniofacial birth defect. The etiology of NSCLP is complex with multiple genes and environmental factors playing causal roles. Although studies have identified numerous genetic markers associated with NSCLP, the role of epigenetic variation remains relatively unexplored. Because of their identical DNA sequences, monozygotic (MZ) twins discordant for NSCLP are an ideal model for examining the potential contribution of DNA methylation to non-syndromic orofacial clefting. In this study, we compared the patterns of whole genome DNA methylation in six MZ twin pairs discordant for NSCLP. Differentially methylated positions (DMPs) and regions (DMRs) were identified in NSCLP candidate genes, including differential methylation in MAFB and ZEB2 in two independent MZ twin pairs. In addition to DNA methylation differences in NSCLP candidate genes, we found common differential methylation in genes belonging to the Hippo signaling pathway, implicating this mechanosensory pathway in the etiology of NSCLP. The results of this novel approach using MZ twins discordant for NSCLP suggests that differential methylation is one mechanism contributing to NSCLP, meriting future studies on the role of DNA methylation in familial and sporadic NSCLP.

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“…On other hand, genioplasty advancement can enlarge the pharyngeal airway space after surgery. Thus, genioplasty advancement alongside mandibular setback (bilateral sagittal split ramus osteotomy) can help in reducing the adverse effects of a pharyngeal airway space reduction [ 26 ]. Lee et al demonstrated that the pharyngeal airway space is narrower in patients with increased BMI, especially after surgery.…”

Section: Reviewmentioning

confidence: 99%

Changes in Pharyngeal Airway Space and Oxygen Saturation Following Mandibular Setback Surgery: A Narrative Review

Fatani¹,

Fatani²,

Fatani³

et al. 2022

Cureus

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Orthognathic surgery can alter the dental, skeletal, soft tissue, and dimensional changes in the oropharyngeal region. Studies have shown a posterior positioning of the hyoid bone and tongue position after mandibular setback surgery, this in turn can have a negative influence on the upper airway space that could lead to breathing problems such as obstructive sleep apnea. Mandibular setback surgery is commonly used for functional and aesthetic correction in mandibular prognathism patients. There are still some controversial opinions regarding the effect of mandibular setback surgery on the pharyngeal airway space and oxygen saturation. This study aims to review and illustrate the changes in pharyngeal airway space and oxygen saturation following mandibular setback surgery.

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Upper Airway Changes After Mandibular Setback and/or Advancement Genioplasty in Obese Patients

Cited by 12 publications

References 31 publications

Changes in the pharyngeal airway after different orthognathic procedures for correction of class III dysplasia

Changes in the pharyngeal airway after different orthognathic procedures for correction of class III dysplasia

DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Non-syndromic Cleft Lip and Palate

Changes in Pharyngeal Airway Space and Oxygen Saturation Following Mandibular Setback Surgery: A Narrative Review

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