UPLC–Q-TOF-MS/MS fingerprinting of Traditional Chinese Formula SiJunZiTang

Characterization of phenolic compounds and antioxidant properties of Glycyrrhiza glabra L. rhizomes and roots

“…Many papers have been published proling phenolic compounds in G. glabra samples from different origins and using different extraction methodologies, some of them cited in the previous discussion. 34,35,[37][38][39][40][41][42][43][44][45][46] However, from all of them, only Montoro et al (2011) presented quantitative results, although they cannot be compared with ours results since they are expressed differently (mg g À1 of dry plant), thus these authors revealed liquiritin apioside as the main avonoid present in their sample, which is in agreement with the sample studied herein. In our case, the results were expressed in mg g À1 of extract in order to relate the amounts of phenolic compounds found in the extract to the antioxidant activity.…”

Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry

“…Rutin (42), quercetin-7-O-glucopyranoside (43), isoquercitrin (55), astragalin (56) and luteoloside (64) have similar fragmentation pathways to produce diagnostic fragment Y 0 (loss of Glc or rutinose group (Glc 6 -1 Rha)), suggesting these compounds are O-glycosyl flavonoids. These compounds produced two diagnostic fragment [28,29,[35][36][37]. Chalcones with C-2 -OH could transform to corresponding flavanone isomers, and then produced the same typical fragment ions via Y 0 and RDA reaction [28,35].…”

“…Chalcones with C-2 -OH could transform to corresponding flavanone isomers, and then produced the same typical fragment ions via Y 0 and RDA reaction [28,35]. [35,36]. Compounds 62, 95 and 103 had one methyl in their structures which characteristic fragmentation behavior was the loss of CH 3 (15 Da), and yielded fragment ions via RDA reaction (A 1,3 , B 1,3 ), So they were deduced as licochalcone B, glycyrrhisoflavanone and licochalcone A, respectively [28,29,35,37].…”

“…In this work, a total of 20 triterpene saponins were identified and showed similar MS/MS behaviors. In the negative ion mode, all saponin compounds [28,29,36,41].…”

Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore extracts

“…Recently, the technique of UHPLC-MS/MS was widely believed to be the best choice for multiple components simultaneous determination in biological samples, and has been widely used to analyze the chemical compounds in TCM for pharmacokinetic purpose [22][23][24][25][26][27][28][29][30]. In this paper, the technique of UHPLC-MS/MS is applied to develop method for simultaneous quantitation of FAN and TET in rat plasma.…”