UPLC-Q-TOF/MS and Network Pharmacology-Based Study on the Mechanism of Qingre Lishi Decoction in Psoriasis Therapyuplc-Q-Tof/Ms and Network Pharmacology-Based Study on the Mechanism of Qingre Lishi Decoction in Psoriasis Therapy

Cao, Zhiqiang; Zhu, Xia; Li, Mingming; Wei, Jingjing; Du, Lin; Han, Changyu; Wu, Jian; Yang, Anbo; Xu, Qingqing; Zhang, Chunhong

doi:10.2139/ssrn.4369310

Cited by 1 publication

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“…A UPLC–TOF–MS–based metabolomics method demonstrated that the dissolution ratio of diol‐type Rb1, Rb3, Rd and their derivatives increased after the combination of PG–OJ ( Ophiopogon japonicus ), whereas that of protopanaxatriol‐type Rg1, F3, and Ro decreased (Li, 2016), indicating that the drug interaction occurred and dissolution of some ginsenosides in ginseng was changed; these events may be the material basis for the synergistic effect and detoxification of PG–OJ. In addition, urine metabonomic studies on rats showed that the combination of PG–OJ played a role in protecting against myocardial injury by regulating the metabolism of purines, amino acids, fat, and energy, providing more evidence for rational drug usage and effective drug development of doxorubicin‐induced myocardial injury in clinical practice.…”

Section: Application Of Metabolomics In the Clinical Study Of Ginsengmentioning

confidence: 99%

Research progress on metabolomics in the quality evaluation and clinical study ofPanax ginseng

Xia

Sun

Wen

et al. 2022

Biomedical Chromatography

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Panax ginseng, an essential component of traditional medicine and often referred to as the king of herbs, has played a pivotal role in medicine globally for several millennia. Previously, traditional phytochemical methods were mainly used for quality evaluation and pharmacological mechanism studies of ginseng, resulting in the lack of systematicness and innovation and hindering the development and utilization of ginseng resources. Since the beginning of the new century, systems biology technology represented by metabolomics has shown unique advantages in the modernization and internationalization of herbal medicine, establishing a bridge for communication between traditional medicine and modern medicine. P. ginseng, a special herb used in medicine and food, is one of the main research objects for qualitative and quantitative analysis of metabolomics and has gradually become the focus of researchers globally. Here, we conducted a comprehensive summary and analysis of numerous studies published in ginseng metabolomics. This review aims to provide more novel ideas for the quality evaluation, development, and clinical application of ginseng in the future and offer more useful technical references for the modernization and internationalization of herbal medicine based on metabolomics.

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Section: Application Of Metabolomics In the Clinical Study Of Ginsengmentioning

confidence: 99%

Research progress on metabolomics in the quality evaluation and clinical study ofPanax ginseng

Xia

Sun

Wen

et al. 2022

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

UPLC-Q-TOF/MS and Network Pharmacology-Based Study on the Mechanism of Qingre Lishi Decoction in Psoriasis Therapyuplc-Q-Tof/Ms and Network Pharmacology-Based Study on the Mechanism of Qingre Lishi Decoction in Psoriasis Therapy

Cited by 1 publication

References 0 publications

Research progress on metabolomics in the quality evaluation and clinical study ofPanax ginseng

Research progress on metabolomics in the quality evaluation and clinical study ofPanax ginseng

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