Upgrading the sleeping brain with targeted memory reactivation

Oudiette, Delphine; Paller, Ken A.

doi:10.1016/j.tics.2013.01.006

Cited by 312 publications

(255 citation statements)

References 92 publications

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“…Previous literature on the effects of sleep on memory indicates that there is a benefit for memories ‘tagged’ during or soon after encoding (Stickgold and Walker, 2013). While several factors can lead to stimuli being tagged as important to remember (Oudiette and Paller, 2013), of particular relevance to the present study is work showing that the sleep‐dependent gain in motor performance is greater for sequences associated with a monetary reward relative to those that are not (Fischer and Born, 2009). Similarly, simply the expectancy of a memory test can lead to sleep‐dependent gains in declarative, procedural, and visuospatial memory (Van Dongen et al ., 2012; Wilhelm et al ., 2011).…”

Section: Introductionmentioning

confidence: 88%

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Bennion

Chee

2016

Journal of Sleep Research

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SummaryAs chronic sleep restriction is a widespread problem among adolescents, the present study investigated the effects of a 1‐week sleep restriction (SR) versus control period on the consolidation of long‐term memory for prose passages. We also determined whether the benefit of prioritization on memory is modulated by adequate sleep occurring during consolidation. Fifty‐six healthy adolescents (25 male, aged 15–19 years) were instructed to remember a prose passage in which half of the content was highlighted (prioritized), and were told that they would receive an additional bonus for remembering highlighted content. Following an initial free recall test, participants underwent a 7‐night period in which they received either a 5‐h (SR) or 9‐h (control) nightly sleep opportunity, monitored by polysomnography on selected nights. Free recall of the passage was tested at the end of the sleep manipulation period (1 week after encoding), and again 6 weeks after encoding. Recall of highlighted content was superior to that of non‐highlighted content at all three time‐points (initial, 1 week, 6 weeks). This beneficial effect of prioritization on memory was stronger 1 week relative to a few minutes after encoding for the control, but not the SR group. N3 duration was similar in the control and SR groups. Overall, the present study shows that the benefits of prioritization on memory are enhanced over time, requiring time and sleep to unfold fully. Partial sleep deprivation (i.e. 5‐h nocturnal sleep opportunity) may attenuate such benefits, but this may be offset by preservation of N3 sleep duration.

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Section: Introductionmentioning

confidence: 88%

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Bennion

Chee

2016

Journal of Sleep Research

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“…Several studies have shown that memory replay and consolidation processes occur during all sleep stages (for reviews, see Diekelmann and Born 2010;Maquet 2001;Oudiette and Paller 2013;Stickgold 2005). Both slow oscillations and sleep spindles during NREM sleep have been reported to be associated with memory (procedural and declarative) consolidation and synaptic plasticity processes (Bergmann et al 2008;Diekelmann and Born 2010;Fogel and Smith 2011;Huber et al 2004;Marshall et al 2006;Rosanova and Ulrich 2005).…”

Section: Off-line Processing and Consolidation Of Emotional Memoriesmentioning

confidence: 99%

“…In addition, neuroimaging studies in humans have demonstrated that NREM and REM sleep may foster lasting neural changes as well as changes in functional connectivity after perceptual, motor, or emotional learning tasks (Maquet et al 2003;Payne and Kensinger 2010;Sterpenich et al 2007). It is supposed that the neural traces coding for newly acquired information are reactivated during subsequent periods of both NREM sleep and/or REM sleep, thus promoting memory consolidation and reorganization (Diekelmann and Born 2010;Maquet et al 2000;Oudiette and Paller 2013;Rasch et al 2007;Rudoy et al 2009). Below we report converging evidence suggesting that the activation of limbic, paralimbic, and reward systems during sleep-with or without concomitant dream experience-serves emotional regulation and memory consolidation processes.…”

Section: Off-line Processing and Consolidation Of Emotional Memoriesmentioning

confidence: 99%

Sleep and Emotional Functions

Perogamvros

Schwartz

2013

Sleep, Neuronal Plasticity and Brain Function

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In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.

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“…By strengthening the overlapping connections between separate memories, the 'gist' emerges that enables generalisation to new stimuli or situations 16,51 . Based on this theory we hypothesised that TMR would, by manipulating the occurrence of spontaneous reactivations 28 , promote the abstraction process through a selective enhancement of the highly likely transitions. Surprisingly, however, we observed the opposite: TMR impaired task performance for both auditory and visual versions of the task and abolished the association with SWS.…”

Section: Discussionmentioning

confidence: 99%

“…According to this idea, the depolarising up-phases of the slow oscillations drive the formation of spindle-ripple events. Spindle-ripple events grouped during slow oscillations may play a key role in hippocampal-neocortical dialogue during sleep 23,[26][27][28] , which may also underlie processes of abstraction and generalisation 16 .…”

Section: Introductionmentioning

confidence: 99%

Cued Memory Reactivation During SWS Abolishes the Beneficial Effect of Sleep on Abstraction

Hennies

Ralph

Durrant

et al. 2017

Sleep

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Study Objectives: Extracting regularities from stimuli in our environment and generalising these to new situations are fundamental processes in human cognition. Sleep has been shown to enhance these processes, possibly by facilitating reactivation-triggered memory reorganisation. Here, we assessed whether cued reactivation during slow wave sleep (SWS) promotes the beneficial effect of sleep on abstraction of statistical regularities. Methods:We used an auditory statistical learning task, in which the benefit of sleep has been firmly established. Participants were exposed to a probabilistically determined sequence of tones, and subsequently tested for recognition of novel short sequences adhering to this same statistical pattern in both immediate and delayed recall sessions. In different groups, the exposure stream was replayed during SWS in the night between the recall sessions (SWS-replay group), in wake just before sleep (pre-sleep replay group), or not at all (control group).Results: Surprisingly, participants who received replay in sleep performed worse in the delayed recall session than the control and the pre-sleep replay group. They also failed to show the association between SWS and task performance that has been observed in previous studies and was present in the controls. Importantly, sleep structure and sleep quality did not differ between groups, suggesting that replay during SWS did not impair sleep, but rather disrupted or interfered with sleep-dependent mechanisms that underlie the extraction of the statistical pattern. Conclusions:These findings raise important questions about the scope of cued memory reactivation and the mechanisms that underlie sleep-related generalisation.

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Upgrading the sleeping brain with targeted memory reactivation

Cited by 312 publications

References 92 publications

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Sleep and Emotional Functions

Cued Memory Reactivation During SWS Abolishes the Beneficial Effect of Sleep on Abstraction

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