Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions

Gibson, Andrew; Deshpande, Pooja; Campbell, Chelsea N.; Krantz, Matthew S.; Mukherjee, Eric M.; Mockenhaupt, Maja; Pirmohamed, Munir; Palubinsky, Amy M.; Phillips, Elizabeth

doi:10.1016/j.jaci.2022.12.005

Cited by 28 publications

(31 citation statements)

References 149 publications

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“…The positive predictive value of an HLA allele for a specific SCAR reaction varies between 2% and 20% for most SCAR. 63 It was as high as 55% for abacavir hypersensitivity. 170 Although there are positive and negative predictive value gaps for HLA associations and SCAR and HLA is thought to be necessary but not sufficient for the development of SCAR if a risk allele is present in an individual, the risk implications are thought to be the same regardless of race and ethnicity.…”

Section: Sc Ar S and G Lobal Epidemi Ology In Rel Ati On To G Ene Tic...mentioning

confidence: 99%

“…This “negative predictive value gap” of HLA for specific drug hypersensitivities will be narrowed in the future with discovery of new HLA associations across more diverse populations. The positive predictive value of an HLA allele for a specific SCAR reaction varies between 2% and 20% for most SCAR 63 . It was as high as 55% for abacavir hypersensitivity 170 .…”

Section: Scars and Global Epidemiology In Relation To Genetic Riskmentioning

confidence: 99%

“…It was as high as 55% for abacavir hypersensitivity 170 . Although there are positive and negative predictive value gaps for HLA associations and SCAR and HLA is thought to be necessary but not sufficient for the development of SCAR if a risk allele is present in an individual, the risk implications are thought to be the same regardless of race and ethnicity 63 . Race and ethnicity targeted pre‐prescription HLA testing is now discouraged 160,171 …”

Section: Scars and Global Epidemiology In Relation To Genetic Riskmentioning

confidence: 99%

“…Most immediate reactions are amenable to desensitization, 59,60 a ground breaking immunotherapy procedure allowing safe reintroduction of culprit drugs. Delayed reactions 61 can be skin‐limited benign reactions associated with long lasting T‐cell memory, single organ toxicity due to nonimmune cell‐receptor interactions, immune complex‐mediate serum sickness‐like reactions, cytotoxic IgG‐mediated reactions, and SCARS such as (DRESS), SJS and TEN, AGEP some of which have been shown to be human leukocyte antigen (HLA) class I alleles restricted 62,63 (Figure 1; Tables 1 and 2) and not amenable to desensitization. In vivo biomarkers 64 include skin testing by skin prick and intradermal methods, patch testing and drug challenges 7,65–67 and in vitro tests include tryptase, interleukin (IL)‐6, basophil activation test (BAT), mast cell activation test (MAT), nanoparticles and genotyping 58,68–75 (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Changing patterns in the epidemiology of drug allergy

Doña,

Torres,

Celik

et al. 2023

Allergy

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Drug allergy (DA) remains a complex and unaddressed problem worldwide that often deprives patients of optimal medication choices and places them at risk for life‐threatening reactions. Underdiagnosis and overdiagnosis are common and due to the lack of standardized definitions and biomarkers. The true burden of DA is unknown, and recent efforts in data gathering through electronic medical records are starting to provide emerging patterns around the world. Ten percent of the general population engaged in health care claim to have a DA, and the most common label is penicillin allergy. Up to 20% of emergency room visits for anaphylaxis are due to DA and 15%–20% of hospitalized patients report DA. It is estimated that DA will increase based on the availability and use of new and targeted antibiotics, vaccines, chemotherapies, biologicals, and small molecules, which are aimed at improving patient's options and quality of life. Global and regional variations in the prevalence of diseases such as human immunodeficiency virus and mycobacterial diseases, and the drugs used to treat these infections have an impact on DA. The aim of this review is to provide an update on the global impact of DA by presenting emerging data on drug epidemiology in adult and pediatric populations.

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Section: Sc Ar S and G Lobal Epidemi Ology In Rel Ati On To G Ene Tic...mentioning

confidence: 99%

Section: Scars and Global Epidemiology In Relation To Genetic Riskmentioning

confidence: 99%

Section: Scars and Global Epidemiology In Relation To Genetic Riskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changing patterns in the epidemiology of drug allergy

Doña,

Torres,

Celik

et al. 2023

Allergy

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“…Cases with 10%-30% epidermal detachment are referred to as SJS-TEN overlap. 106 The average reported mortality rate for SJS was between 5%…”

Section: Cutaneous Reactionsmentioning

confidence: 99%

Tissue‐resident memory T cells in immunotherapy and immune‐related adverse events by immune checkpoint inhibitor

Xiong,

Shen

2024

Intl Journal of Cancer

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Tissue‐resident memory T cells (TRM) are a specialized subset of T cells that reside in tissues and provide long‐term protective immunity against pathogens that enter the body through that specific tissue. TRM cells have specific phenotype and reside preferentially in barrier tissues. Recent studies have revealed that TRM cells are the main target of immune checkpoint inhibitor immunotherapy since their role in cancer immunosurveillance. Furthermore, TRM cells also play a crucial part in pathogenesis of immune‐related adverse events (irAEs). Here, we provide a concise review of biological characteristics of TRM cells, and the major advances and recent findings regarding their involvement in immune checkpoint inhibitor immunotherapy and the corresponding irAEs.

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