Updates on Old and Weary Haematopoiesis

Konieczny, Joanna; Arranz, Lorena

doi:10.3390/ijms19092567

Cited by 25 publications

(12 citation statements)

References 94 publications

(132 reference statements)

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“…Comparing within each age group, the highest proportion of leukemia (35.5%) was seen among patients older than 50 years of age while there was a similar proportion between age groups 0-14 and 15-49 (32.3% each) (p < 0.0001). is high preponderance of older adults for leukemia may be mainly due to advancement of age where many environmental exposures to carcinogens, irradiations, and malignant mutations due to clonal expansion occur more frequently [27,28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Kassahun

Tesfaye

Bimerew

et al. 2020

Advances in Hematology

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Introduction. Leukemia is a heterogeneous group of hematological disorder which comprise several diverse and biologically distinct subgroups. Leukemia represents the 11th and 10th most frequent cause of cancer morbidity and mortality worldwide, respectively. Adequate data regarding the prevalence of leukemia are lacking in Ethiopia, particularly in the study area. This study is aimed to determine the prevalence of leukemia and associated factors among patients who have abnormal hematological parameters in Jimma Medical Center. Methodology. A facility-based cross-sectional study was conducted involving 332 patients who have abnormal hematological parameters. Complete blood count from venous blood was made with Sysmex autohematology analyzer (Sysmex XS-500i and XT-1800; Kobe, Japan). Peripheral blood morphology and bone marrow aspirate examination were done for each patient. Descriptive statistics for the prevalence of leukemia and multinomial logistic regression analysis to assess associated factors were executed with IBM SPSS version 25. Results. The prevalence of leukemia was 9.3%, while acute myeloid leukemia, Acute Lymphoid Leukemia, Chronic Myeloid Leukemia, Chronic Lymphoid Leukemia, Myelodysplastic Syndrome, and undifferentiated leukemia comprises 3.6%, 2.7%, 1.8%, 0.6%, and 0.3%, respectively. Older Age ( p = 0.019 ), being male ( p = 0.047 ), being anemic ( p = 0.03 ), and rural residency of a patient ( p = 0.044 ) were significantly associated with having acute myeloid leukemia. Conclusion. The prevalence of leukemia among patients who have abnormal hematological parameters in Jimma Medical Center is significant which needs further comprehensive investigations of the associated factors and predictors with more up to date diagnostic methods.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Kassahun

Tesfaye

Bimerew

et al. 2020

Advances in Hematology

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“…Interestingly, most studies on the role of BMA in the HSC niche have focused on their potential support of HSC survival/proliferation, with little attention to the possible facilitation of HSC differentiation. However, myeloid skewing is a common event in obesity, diabetes, myeloid malignancies, and aging [162]; all conditions with increased BMA. Considering that extramedullary hematopoiesis in adipose tissue is preferentially axed towards the myeloid lineage [163,164], the involvement of BMA in such a process in the BM under health and disease should be subject of future work.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche

Cuminetti

Arranz

2019

JCM

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Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and functional responses, depending on their location in the BM. BMA also show remarkable differences among species and between genders, they progressively replace the hematopoietic BM throughout aging, and play roles in a range of pathological conditions such as obesity, diabetes and anorexia. They are a crucial component of the BM microenvironment that regulates hematopoiesis, through mechanisms largely unknown. Previously considered as negative regulators of hematopoietic stem cell function, recent data demonstrate their positive support for hematopoietic stem cells depending on the experimental approach. Here, we further discuss current knowledge on the role of BMA in hematological malignancies. Early hints suggest that BMA may provide a suitable metabolic niche for the malignant growth of leukemic stem cells, and protect them from chemotherapy. Future in vivo functional work and improved isolation methods will enable determining the true essence of this elusive BM hematopoietic stem cell niche component, and confirm their roles in a range of diseases. This promising field may open new pathways for efficient therapeutic strategies to restore hematopoiesis, targeting BMA.

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“…The immune system's aforementioned diversity stems from it being comprised of various cells, all different in form and function. Despite its diversity, all cells of the immune system descend from the HSC niches in the bone marrow, which are tended to all cells of the osseous line, mesenchymal cells and endosteal cells (86). Depending on developmental factors secreted from these local cells, the stem and progenitor cells commit to different lines of evolution (Table 1) (85).…”

Section: Main Components Of the Immune System Viewed In Relation To Osseous Developmentmentioning

confidence: 99%

Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System

et al. 2020

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Immunology, already a discipline in its own right, has become a major part of many different medical fields. However, its relationship to orthopedics and trauma surgery has unfortunately, and perhaps unjustly, been developing rather slowly. Discoveries in recent years have emphasized the immense breadth of communication and connection between both systems and, importantly, the highly promising therapeutic opportunities. Recent discoveries of factors originally assigned to the immune system have now also been shown to have a significant impact on bone health and disease, which has greatly changed how we approach treatment of bone pathologies. In case of bone fracture, immune cells, especially macrophages, are present throughout the whole healing process, assure defense against pathogens and discharge a complex variety of effectors to regulate bone modeling. In rheumatoid arthritis and osteoporosis, the immune system contributes to the formation of the pathological and chronic conditions. Fascinatingly, prosthesis failure is not at all solely a mechanical problem of improper strain but works in conjunction with an active contribution of the immune system as a reaction to irritant debris from material wear. Unraveling conjoined mechanisms of the immune and osseous systems heralds therapeutic possibilities for ailments of both. Contemplation of the bone as merely an unchanging support pillar is outdated and obsolete. Instead it is mandatory that this highly diverse network be incorporated in our understanding of the immune system and hematopoiesis.

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Updates on Old and Weary Haematopoiesis

Cited by 25 publications

References 94 publications

Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche

Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System

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