Updates in the diagnosis and management of small-bowel tumors

Vlachou, Erasmia; Koffas, Apostolos; Toumpanakis, Christos; Keuchel, Martin

doi:10.1016/j.bpg.2023.101860

Cited by 8 publications

(6 citation statements)

References 85 publications

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“…To exclude a different primary site than the orbit, a CT scan of the abdomen and thorax is suggested. Given that the majority of orbital localizations originate from primary intestinal NENs [13,70], the use of CT enterography (CTE) or MR enterography (MRE) can be useful to detect small bowel lesions, especially if the signs and symptoms of carcinoid syndrome are noted [85,86]. El-Toukhy described a case of orbital carcinoid with several local recurrences that was diagnosed six years before the detection of ileal NEN.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation

Arrivi,

Specchia,

Pilozzi

et al. 2024

Biomedicines

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Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant’Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation

Arrivi,

Specchia,

Pilozzi

et al. 2024

Biomedicines

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“…Computed tomography (CT), magnetic resonance imaging (MRI) enterography, and CT enterography, along with device-assisted enteroscopy, are the most commonly used radiological techniques for the detection of small bowel cancers, yielding effective results. [ 5 - 6 ] In our study, 28 (82.3%) patients underwent oral/intravenous (IV) contrast-enhanced CT as a diagnostic method. A mass in the duodenum was seen in nine patients, in ileum in eight patients, and in the jejunum in nine patients.…”

Section: Discussionmentioning

confidence: 99%

Emergent approach to small bowel tumors: diagnosis and treatment

Sahin

2024

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: This study presents the diagnosis and treatment of rare small bowel tumors through clinical cases. METHODS: Patients treated between 2000 and 2023 were included in the study. The clinical records of the patients were analyzed retrospectively. RESULTS: A total of 34 patients were included in the study. Of these patients, 26 (75.5%) were male and eight (23.5%) were female. The mean age of the patients was 62.1 years. The most common symptoms and signs were abdominal pain (76.4%), bloating (38.2%), and nausea and vomiting (17.6%). Diagnostic methods included computed tomography (CT) (82.3%), upper gastrointestinal double balloon enteroscopy (35.2%), and capsule endoscopy (5.8%). Diagnoses included adenocarcinoma in 13 cases, gastrointestinal stromal tumors (GISTs) in 12 cases, and neuroendocrine tumors (NETs) in two cases. CONCLUSION: Small bowel tumors frequently present with abdominal pain, bloating, and nausea and vomiting. CT and endoscopic procedures are the primary diagnostic tools. Small bowel cancers are often diagnosed late due to subtle clinical findings and the limitations of endoscopic imaging. Targeted screening strategies may be beneficial for certain at-risk and symptomatic patient groups. Early surgical intervention offers significant advantages for diagnosed patients.

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“…The most common primary malignant lesions are neuroendocrine tumors (NETs), followed by adenocarcinomas, lymphomas, and sarcomas (among which, GI stromal tumor (GIST) is the most frequent) [3]. Although the prevalence of subtypes may vary geographically [4], the rarity and non-specific subtle clinical presentation of these entities often make the diagnostic pathway extremely challenging. The early detection of SBTs is of paramount importance to improve the patient's prognosis, keeping in mind that in most cases a definitive diagnosis is obtained using a combination of several diagnostic techniques.…”

Section: Background and Definitionsmentioning

confidence: 99%

The Role of Capsule Endoscopy in the Diagnosis and Management of Small Bowel Tumors: A Narrative Review

Fantasia,

Cortegoso Valdivia,

Kayali

et al. 2024

Cancers

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Small bowel tumors (SBT) are relatively rare, but have had a steadily increasing incidence in the last few decades. Small bowel capsule endoscopy (SBCE) and device-assisted enteroscopy are the main endoscopic techniques for the study of the small bowel, the latter additionally providing sampling and therapeutic options, and hence acting complementary to SBCE in the diagnostic work-up. Although a single diagnostic modality is often insufficient in the setting of SBTs, SBCE is a fundamental tool to drive further management towards a definitive diagnosis. The aim of this paper is to provide a concise narrative review of the role of SBCE in the diagnosis and management of SBTs.

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Updates in the diagnosis and management of small-bowel tumors

Cited by 8 publications

References 85 publications

Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation

Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation

Emergent approach to small bowel tumors: diagnosis and treatment

The Role of Capsule Endoscopy in the Diagnosis and Management of Small Bowel Tumors: A Narrative Review

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