Update on the Medical Management of Corneal and External Eye Diseases, Corneal Transplantation, and Keratorefractive Surgery

Sustained Intraocular Rapamycin Delivery Effectively Prevents High-Risk Corneal Allograft Rejection and Neovascularization in Rabbits

“…The rejection rate is approximately 20% for low-risk corneal grafts, but it is between 60% and 90% for high-risk keratoplasties with cornea vascularization. 15,16 Corneal neovascularization is the major cause of high-risk keratoplasty. Neither topical nor systemic administration of corticosteroids has been successful for prophylaxis or treatment of the rejection episode in patients at high risk.…”

Sustained Intraocular Rapamycin Delivery Effectively Prevents High-Risk Corneal Allograft Rejection and Neovascularization in Rabbits

“…The rejection rate is approximately 20% for low-risk corneal grafts, but it is between 60% and 90% for high-risk keratoplasties with cornea vascularization. 15,16 Corneal neovascularization is the major cause of high-risk keratoplasty. Neither topical nor systemic administration of corticosteroids has been successful for prophylaxis or treatment of the rejection episode in patients at high risk.…”

A comparison of the precorneal residence of an artificial tear preparation in patients with keratoconjunctivitis sicca and normal volunteer subjects using gamma scintigraphy

“…Dry eye patients are especially susceptible to the effect of bacterial toxins and preservatives in medi-cations. In addition, the frequent use of artificial tears containing preservatives such as benzalkonium chloride, a detergent contained in the artificial tear solution studied, can be counterproductive as it can decrease the stability of the tear film and concentrate on the dry eye by evaporation, and patients with KCS may develop a superimposed keratitis medicamentosa as a complication of the treatment (Stern 1988).…”

Efeito imunossupressor da ciclosporina intra-muscular administrada em diferentes períodos pós-operatórios em um modelo de transplante penetrante de córnea em ratos

“…(3) Mestre em Oftalmologia pela UNIFESP. (4) Acadêmico do 6º ano do Curso de Medicina da FURB -Universidade Regional de Blumenau. (5) Professor Orientador de Pós-Graduação da UNIFESP.…”

“…Blumenau (SC). CEP 89015-200. e-mail: rhertwig@zaz.com.br Roberto von Hertwig (1) Moacyr Pezati Rigueiro (2) Paulo Dantas Rodrigues (3) Franco Amboni Nunes Tôrres (4) Mauro Nishi (5) RESUMO Palavras-chave: Ciclosporina A; Transplante de córnea experimental; Rejeição do enxerto.…”

“…O uso de corticosteróides controla apenas aproximadamente 50% dos casos de córneas rejeitadas 4 e se justifica portanto o interesse sobre novas formas de prevenção e tratamento para o grupo de transplantes de córnea com alto risco de rejeição. Vários autores demonstraram aumento no tempo de sobrevida dos enxertos de córnea, utilizando a ciclosporina (CSA) em diferentes animais, por períodos limitados 2,5 .…”

Sustained Intraocular Rapamycin Delivery Effectively Prevents High-Risk Corneal Allograft Rejection and Neovascularization in Rabbits

“…The rejection rate is approximately 20% for low-risk corneal grafts, but it is between 60% and 90% for high-risk keratoplasties with cornea vascularization. 15,16 Corneal neovascularization is the major cause of high-risk keratoplasty. Neither topical nor systemic administration of corticosteroids has been successful for prophylaxis or treatment of the rejection episode in patients at high risk.…”

A comparison of the precorneal residence of an artificial tear preparation in patients with keratoconjunctivitis sicca and normal volunteer subjects using gamma scintigraphy

“…Dry eye patients are especially susceptible to the effect of bacterial toxins and preservatives in medi-cations. In addition, the frequent use of artificial tears containing preservatives such as benzalkonium chloride, a detergent contained in the artificial tear solution studied, can be counterproductive as it can decrease the stability of the tear film and concentrate on the dry eye by evaporation, and patients with KCS may develop a superimposed keratitis medicamentosa as a complication of the treatment (Stern 1988).…”

Efeito imunossupressor da ciclosporina intra-muscular administrada em diferentes períodos pós-operatórios em um modelo de transplante penetrante de córnea em ratos

“…(3) Mestre em Oftalmologia pela UNIFESP. (4) Acadêmico do 6º ano do Curso de Medicina da FURB -Universidade Regional de Blumenau. (5) Professor Orientador de Pós-Graduação da UNIFESP.…”

“…Blumenau (SC). CEP 89015-200. e-mail: rhertwig@zaz.com.br Roberto von Hertwig (1) Moacyr Pezati Rigueiro (2) Paulo Dantas Rodrigues (3) Franco Amboni Nunes Tôrres (4) Mauro Nishi (5) RESUMO Palavras-chave: Ciclosporina A; Transplante de córnea experimental; Rejeição do enxerto.…”

“…O uso de corticosteróides controla apenas aproximadamente 50% dos casos de córneas rejeitadas 4 e se justifica portanto o interesse sobre novas formas de prevenção e tratamento para o grupo de transplantes de córnea com alto risco de rejeição. Vários autores demonstraram aumento no tempo de sobrevida dos enxertos de córnea, utilizando a ciclosporina (CSA) em diferentes animais, por períodos limitados 2,5 .…”

Sustained Intraocular Rapamycin Delivery Effectively Prevents High-Risk Corneal Allograft Rejection and Neovascularization in Rabbits

“…The rejection rate is approximately 20% for low-risk corneal grafts, but it is between 60% and 90% for high-risk keratoplasties with cornea vascularization. 15,16 Corneal neovascularization is the major cause of high-risk keratoplasty. Neither topical nor systemic administration of corticosteroids has been successful for prophylaxis or treatment of the rejection episode in patients at high risk.…”

A comparison of the precorneal residence of an artificial tear preparation in patients with keratoconjunctivitis sicca and normal volunteer subjects using gamma scintigraphy

“…Dry eye patients are especially susceptible to the effect of bacterial toxins and preservatives in medi-cations. In addition, the frequent use of artificial tears containing preservatives such as benzalkonium chloride, a detergent contained in the artificial tear solution studied, can be counterproductive as it can decrease the stability of the tear film and concentrate on the dry eye by evaporation, and patients with KCS may develop a superimposed keratitis medicamentosa as a complication of the treatment (Stern 1988).…”

Efeito imunossupressor da ciclosporina intra-muscular administrada em diferentes períodos pós-operatórios em um modelo de transplante penetrante de córnea em ratos

“…(3) Mestre em Oftalmologia pela UNIFESP. (4) Acadêmico do 6º ano do Curso de Medicina da FURB -Universidade Regional de Blumenau. (5) Professor Orientador de Pós-Graduação da UNIFESP.…”

“…Blumenau (SC). CEP 89015-200. e-mail: rhertwig@zaz.com.br Roberto von Hertwig (1) Moacyr Pezati Rigueiro (2) Paulo Dantas Rodrigues (3) Franco Amboni Nunes Tôrres (4) Mauro Nishi (5) RESUMO Palavras-chave: Ciclosporina A; Transplante de córnea experimental; Rejeição do enxerto.…”

“…O uso de corticosteróides controla apenas aproximadamente 50% dos casos de córneas rejeitadas 4 e se justifica portanto o interesse sobre novas formas de prevenção e tratamento para o grupo de transplantes de córnea com alto risco de rejeição. Vários autores demonstraram aumento no tempo de sobrevida dos enxertos de córnea, utilizando a ciclosporina (CSA) em diferentes animais, por períodos limitados 2,5 .…”