Update on the genetics of the fibromyalgia syndrome

Ablin, Jacob N.; Buskila, Dan

doi:10.1016/j.berh.2015.04.018

Cited by 78 publications

(60 citation statements)

References 71 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Familial predisposition and genetic polymorphisms have been identified with candidate genes associated with FM including the serotonin 5-HT2A receptor polymorphism T/T phenotype, serotonin transporter, dopamine 4 receptor and COMT (catechol O-methyltransferase) polymorphisms [23]. These polymorphisms affect metabolism or transport of monoamines and as identified play a role in sensory pain processing and human stress response.…”

Section: Harris Et Almentioning

confidence: 98%

Potential drug therapies for the treatment of fibromyalgia

Lawson

2016

Expert Opinion on Investigational Drugs

View full text Add to dashboard Cite

Modest improvement of health status in patients with FM has been observed with drugs targeting a diverse range of molecular mechanisms. No single drug, however, offered substantial efficacy against all the symptoms characteristic of FM. Identification of new and improved therapies for FM needs to address the heterogeneity of the condition, which suggests existence of patient subgroups, the relationship of central and peripheral aspects of the pathophysiology and a requirement of combination therapy with drugs targeting multiple molecular mechanisms.

show abstract

Section: Harris Et Almentioning

confidence: 98%

Potential drug therapies for the treatment of fibromyalgia

Lawson

2016

Expert Opinion on Investigational Drugs

View full text Add to dashboard Cite

show abstract

“…Since it is frequently seen in people in the same family, it is thought that it has a genetic origin [1]. In the diagnosis of the FS, we see some heterogeneous disorders which contains neuroendocrine, neuropsychiatric and autonomous systems.…”

Section: Introductionmentioning

confidence: 99%

Is having O blood type a risk factor for Fibromyalgia syndrome? The importance of nutrition in Fibromyalgia syndrome

2017

View full text Add to dashboard Cite

Aim: Fibromyalgia syndrome (FS) is characterized with diffuse pain and sensitivity at specific anatomical points and occurs together with mood, sleep and cognitive disorders. Life quality of the patients was destroyed and this situation creates an important economical issue in the medical care system.According to different antigens placed on the surface of red blood cells, there are four different blood type groups such as A, B, O and AB. To give nutritional recommendations for different blood types became one of the most popular topics in last decades. In this study, we investigated the link between FS and ABO blood types.Methods: In this study, we included 200 female patients with FS diagnosis (according to American College of Rheumatology, 2010 criteria) who visited our Physical Medicine and Rehabilitation Clinic between July 2015 and December 2015. The patients' age, blood group, Rh antigen system were saved. Control group was also formed from 185 volunteer healthy female patients. P<0.05 was evaluated as statistically significant.Results: In our study, age distribution of FS group (N=200) was 40.6±10.8 and for control group (N=185), it was 43.0±14.8. In the control group, 58 people was A type (%31,4), 29 people was B type (%15.7), 23 people was AB type (%12.4) and 75 people (40.5%) was O type blood group according to ABO classification system. In the FS group, 60 people was A type (%30), 21 people was B type (%10.5), 10 people was AB type (%5) and 109 people (54.5%) was O type blood group according to ABO classification system. In both groups, a statistically significant difference was observed (p=0.03). There were more O type blood group carrying patients were detected in FS group.Conclusion: Most of the treatments used for FS are not effective. In order to decrease oxidative stress, weight management, nutritional condition, diet and nutrition supplement are important in these patients. To see more O type carrying people in FS group will guide us for etiopathogenesis, monitoring, clinical follow and treatment.Keywords: fibromyalgia -ABO blood type -nutrition. тҰжЫРЫМДАМА Мақсаты: Фибромиалгия синдромы (Фс) белгілі анатомиялық нүктелердегі араласқан ауыру мен сезімталдықпен сипатталады және көңіл-күйдің, ұйқының және таным қабілетінің бұзылуымен пайда болады. Осындай пациенттердің өмір сүру сапасы бұзылған және бұл жағдай денсаулық сақтау жүйесінде маңызды экономикалық проблема тудырады.Эритроциттердің бетіне орналасқан әртүрлі антиденелерге сәйкес А, В, О және АВ сияқты қан топтарының әр түрлері бар. Қан тобының әр түрлері үшін тамақтану бойынша ұсыныстар беру соңғы онжылдықта ең өзекті тақырыптардың бірі болды. Осы зерттеуде біз ФС мен АВО қан тобының түрлері арасындағы байланысты зерттедік.

show abstract

“…The genetic studies in FM have found that short allele of 5-HTTLPR polymorphism is associated with decline in 5-HTT expression and is a risk factor for developing the disease, similarly to migraine. The T102C polymorphism in HTR2A gene encoding 5-HT2A is also postulated to be a risk factor for FM [38]. As 5-HT2 and 5-HT3 are involved in pain perception, the treatment with 5-HT3 antagonist or inhibition of 5-HT reuptake is effective in FM patients [39].…”

Section: Serotonin and Its Metabolites In Migrainementioning

confidence: 99%

Serotonin in Neurological Diseases

Dorszewska¹,

Florczak-Wyspiańska²,

Kowalska³

et al. 2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

View full text Add to dashboard Cite

Serotonin (5-HT) is responsible for anxiety, aggression, and stress. Alterations in a serotonergic system play a significant role in pathogenesis of neurological diseases and neuropsychiatric disorders. A wide range of disturbances associated with serotonergic neurotransmission results from different functions of 5-HT in a nervous system. It is believed that 5-HT may be involved in the pathogenesis of migraine, epilepsy, Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). In these diseases, disturbances of 5-HT and its metabolites, such as 5-hydroxyindoleacetic acid (5-HIAA), were observed in the plasma, blood platelets, and cerebrospinal fluid (CSF). Changes in the level of this biogenic amine (5-HT) may be associated with malfunction of 5-HT receptors, reuptake transporter for 5-HT (5-HTT, SERT), the enzymes responsible for the synthesis and metabolism of 5-HT, and genetic variants for serotonergic system. It seems that 5-HT and its metabolites may be used as a diagnostic and prognostic marker for neurological diseases or a target for more efficient therapy in neurology in the future.

show abstract

Update on the genetics of the fibromyalgia syndrome

Cited by 78 publications

References 71 publications

Potential drug therapies for the treatment of fibromyalgia

Potential drug therapies for the treatment of fibromyalgia

Is having O blood type a risk factor for Fibromyalgia syndrome? The importance of nutrition in Fibromyalgia syndrome

Serotonin in Neurological Diseases

Contact Info

Product

Resources

About