Update on state‐of‐the‐art for arterial spin labeling (<scp>ASL</scp>) human perfusion imaging outside of the brain

Taso, Manuel; Aramendía‐Vidaurreta, Verónica; Englund, Erin K; Francis, Susan T.; Franklin, Suzanne L.; Madhuranthakam, Ananth J.; Martirosian, Petros; Nayak, Krishna S.; Qin, Qin; Shao, Xingfeng; Thomas, David L.; Zun, Zungho; Fernández‐Seara, María A.

doi:10.1002/mrm.29609

Cited by 21 publications

(16 citation statements)

References 159 publications

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“…ASL perfusion imaging has several applications in the body. Taso provided an overview highlighting the ongoing challenges and solutions to enable more widespread use of this technique in clinical practice [ 93 ].…”

Section: Measures To Reduce Gbcamentioning

confidence: 99%

Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents

Dekker,

Stroomberg,

Van der Molen

et al. 2024

Insights Imaging

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Gadolinium-based contrast agents (GBCA) are essential for diagnostic MRI examinations. GBCA are only used in small quantities on a per-patient basis; however, the acquisition of contrast-enhanced MRI examinations worldwide results in the use of many thousands of litres of GBCA per year. Data shows that these GBCA are present in sewage water, surface water, and drinking water in many regions of the world. Therefore, there is growing concern regarding the environmental impact of GBCA because of their ubiquitous presence in the aquatic environment. To address the problem of GBCA in the water system as a whole, collaboration is necessary between all stakeholders, including the producers of GBCA, medical professionals and importantly, the consumers of drinking water, i.e. the patients. This paper aims to make healthcare professionals aware of the opportunity to take the lead in making informed decisions about the use of GBCA and provides an overview of the different options for action.In this paper, we first provide a summary on the metabolism and clinical use of GBCA, then the environmental fate and observations of GBCA, followed by measures to reduce the use of GBCA. The environmental impact of GBCA can be reduced by (1) measures focusing on the application of GBCA by means of weight-based contrast volume reduction, GBCA with higher relaxivity per mmol of Gd, contrast-enhancing sequences, and post-processing; and (2) measures that reduce the waste of GBCA, including the use of bulk packaging and collecting residues of GBCA at the point of application.Critical relevance statement This review aims to make healthcare professionals aware of the environmental impact of GBCA and the opportunity for them to take the lead in making informed decisions about GBCA use and the different options to reduce its environmental burden.Key points• Gadolinium-based contrast agents are found in sources of drinking water and constitute an environmental risk.• Radiologists have a wide spectrum of options to reduce GBCA use without compromising diagnostic quality.• Radiology can become more sustainable by adopting such measures in clinical practice. Graphical Abstract

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Section: Measures To Reduce Gbcamentioning

confidence: 99%

Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents

Dekker,

Stroomberg,

Van der Molen

et al. 2024

Insights Imaging

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“…ASL is an MRI technique that produces a quantitative map of perfusion in the target organ of interest by using arterial blood water as an endogenous contrast agent. Its use in perfusion imaging outside of the brain was reviewed recently [56,95]. The PARENCHIMA consensus paper on kidney ASL recommended that only cortical perfusion should be reported because medullary ASL measurements are not reliable [55].…”

Section: Arterial Spin Labellingmentioning

confidence: 99%

Magnetic Resonance Imaging in Clinical Trials of Diabetic Kidney Disease

Friedli

Baid-Agrawal

Unwin

et al. 2023

JCM

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Chronic kidney disease (CKD) associated with diabetes mellitus (DM) (known as diabetic kidney disease, DKD) is a serious and growing healthcare problem worldwide. In DM patients, DKD is generally diagnosed based on the presence of albuminuria and a reduced glomerular filtration rate. Diagnosis rarely includes an invasive kidney biopsy, although DKD has some characteristic histological features, and kidney fibrosis and nephron loss cause disease progression that eventually ends in kidney failure. Alternative sensitive and reliable non-invasive biomarkers are needed for DKD (and CKD in general) to improve timely diagnosis and aid disease monitoring without the need for a kidney biopsy. Such biomarkers may also serve as endpoints in clinical trials of new treatments. Non-invasive magnetic resonance imaging (MRI), particularly multiparametric MRI, may achieve these goals. In this article, we review emerging data on MRI techniques and their scientific, clinical, and economic value in DKD/CKD for diagnosis, assessment of disease pathogenesis and progression, and as potential biomarkers for clinical trial use that may also increase our understanding of the efficacy and mode(s) of action of potential DKD therapeutic interventions. We also consider how multi-site MRI studies are conducted and the challenges that should be addressed to increase wider application of MRI in DKD.

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“…A consensus statement of recommended implementations of ASL perfusion imaging for clinical applications (ASL White Paper 1 ), published by an expert group of members of the ISMRM Perfusion SG and the European Consortium for ASL in Dementia (COST Action BM1103).Brain Image Data Structure (BIDS) extension for ASL 4 (referred to as ASL‐BIDS in this paper): A community effort to standardize how to organize and share neuroimaging datasets, which was extended to include ASL in 2021 ( https://bids‐specification.readthedocs.io/en/stable/04‐modality‐specific‐files/01‐magnetic‐resonance‐imaging‐data.html#arterial‐spin‐labeling‐perfusion‐data).Technical recommendations for renal ASL 5 from an international group of experts working under the framework of “Magnetic Resonance Imaging Biomarkers for Chronic Kidney Diseases (PARENCHIMA)”, funded by the EU COST Action CA16103 (referred to here as PARENCHIMA renal ASL ).A series of extensions to the ASL White Paper (referred to as the ASL Gray Papers in this paper) on the following topics: “Velocity‐Selective Arterial Spin Labeling Perfusion MRI: A Review of the State of the Art and Recommendations for Clinical Implementation.” 6 “Recent Technical Developments in ASL: A Review of the State of the Art.” 7 “Current State and Guidance on Arterial Spin Labeling Perfusion MRI in Clinical Neuroimaging.” 2 “Update on State‐of‐the‐Art for Arterial Spin Labeling (ASL) Human Perfusion Imaging Outside of the Brain.” 8 Quantitative Cerebral Perfusion MRI Using Multi‐Timepoint Arterial Spin Labeling: Recommendations and Clinical Applications (preprint 9 ). …”

Section: Introductionmentioning

confidence: 99%

ASL lexicon and reporting recommendations: A consensus report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)

Suzuki,

Clement,

Dai

et al. 2023

Magnetic Resonance in Med

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The 2015 consensus statement published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group and the European Cooperation in Science and Technology ( COST) Action ASL in Dementia aimed to encourage the implementation of robust arterial spin labeling (ASL) perfusion MRI for clinical applications and promote consistency across scanner types, sites, and studies. Subsequently, the recommended 3D pseudo‐continuous ASL sequence has been implemented by most major MRI manufacturers. However, ASL remains a rapidly and widely developing field, leading inevitably to further divergence of the technique and its associated terminology, which could cause confusion and hamper research reproducibility.On behalf of the ISMRM Perfusion Study Group, and as part of the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI), the ASL Lexicon Task Force has been working on the development of an ASL Lexicon and Reporting Recommendations for perfusion imaging and analysis, aiming to (1) develop standardized, consensus nomenclature and terminology for the broad range of ASL imaging techniques and parameters, as well as for the physiological constants required for quantitative analysis; and (2) provide a community‐endorsed recommendation of the imaging parameters that we encourage authors to include when describing ASL methods in scientific reports/papers.In this paper, the sequences and parameters in (pseudo‐)continuous ASL, pulsed ASL, velocity‐selective ASL, and multi‐timepoint ASL for brain perfusion imaging are included. However, the content of the lexicon is not intended to be limited to these techniques, and this paper provides the foundation for a growing online inventory that will be extended by the community as further methods and improvements are developed and established.

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Update on state‐of‐the‐art for arterial spin labeling (ASL) human perfusion imaging outside of the brain

Cited by 21 publications

References 159 publications

Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents

Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents

Magnetic Resonance Imaging in Clinical Trials of Diabetic Kidney Disease

ASL lexicon and reporting recommendations: A consensus report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)

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