Up-regulation of the expressions of MiR-149-5p and MiR-99a-3p in exosome inhibits the progress of pituitary adenomas

Zhao, Peng; Cheng, Jianhua; Li, Bin; Nie, Ding; Li, Chuzhong; Gui, Songbai; Wang, Hongyun; Zhang, Yazhou

doi:10.1007/s10565-020-09570-0

Cited by 25 publications

(21 citation statements)

References 57 publications

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“…Considering the function of lncRNAs as sponges for microRNAs, we discovered that HOXC-AS1 may directly sponge miR-99a-3p ( Figure 3 A,B). It was reported that miR-99a-3p loaded exosomes affected cell viability, metastasis and vascular formation ability of invasive pituitary adenoma (IPA) [ 24 ]. Studies also revealed that non-SMC condensin I complex subunit G (NCAPG) could be the downstream target of miR-99a-3p in prostate cancer cells, and distinctly influenced proliferation, migration and invasion [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA HOXC-AS1 Sponges miR-99a-3p and Upregulates MMP8, Ultimately Promoting Gastric Cancer

Jiang

Yang

et al. 2022

Cancers

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Gastric cancer (GC) is among the most lethal tumors worldwide. Long noncoding RNAs (lncRNAs) are reported to be critical during the occurrence and progression of malignancies. The HOXC cluster antisense RNA 1 (HOXC-AS1) has been suggested to participate in the genesis and development of GC. Therefore, we examined GC cells and tissues for the expression of HOXC-AS1 and correlated the expression levels with the disease specific survival of the patients, finding that HOXC-AS1 was overexpressed and probably had a tendency of leading to a poor prognosis. The Cell Counting Kit-8 assay and colony formation assay were then performed under knockdown of HOXC-AS1, revealing that cell proliferation of GC was distinctly decreased. Afterwards, miR-99a-3p was predicted to bind with HOXC-AS1 by DIANA tools. We carried out dual-luciferase reporter gene assays to identify the interaction between them. After knockdown of HOXC-AS1, miR-99a-3p was clearly overexpressed in GC cells. In addition, matrix metalloproteinase 8 (MMP8) was shown to be combined with miR-99a-3p using TargetScan. Similar experiments, along with western blot, were conducted to validate the correlation between miR-99a-3p and MMP8. Finally, rescue experiments for CCK-8 were completed, disclosing that HOXC-AS1 promoted cell progression of GC through sponging miR-99a-3p followed by subsequent upregulation of MMP8.

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Section: Discussionmentioning

confidence: 99%

LncRNA HOXC-AS1 Sponges miR-99a-3p and Upregulates MMP8, Ultimately Promoting Gastric Cancer

Jiang

Yang

et al. 2022

Cancers

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“…Not only coding genes have been related to EMT in pituitary tumors, some microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to modulate EMT. MiR-149-5p and miR-99a-3p suppress the expression of EMT-related genes (34). miR-132, miR-15a and miR-16 also inhibit EMT in pituitary adenomas; in this case targeting SOX5 (35).…”

Section: Epithelial-mesenchymal Transition In Pituitary Tumorsmentioning

confidence: 98%

Epithelial–Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly

et al. 2021

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Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. Pituitary tumors, although typically benign, can be locally invasive. Different studies have shown the association of EMT with increased tumor size and invasion in pituitary tumors, and in particular with a poor response to Somatostatin Receptor Ligands (SRLs) treatment in GH-producing pituitary tumors, the main cause of acromegaly. This review will summarize the current knowledge regarding EMT and SRLs resistance in acromegaly and, based on this relation, will suggest new biomarkers and possible therapies to SRLs resistant tumors.

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“…The study on miRNAs is a fine point to elaborate the pathogenesis underlying PAs. Upregulation of the expressions of miR-149-5p and miR-99a-3p in exosomes was shown to inhibit the progress of PA cells [20]. A study using bioinformatic analysis identified that hsa-miR-489 and hsa-miR-520b might provide new clues for the diagnosis and treatment of aggressive PRL-PA [21].…”

Section: Regulation Of Mirnas In Pa Invasion and Metastasismentioning

confidence: 99%

The Involvement of miRNAs in Pituitary Adenomas Pathogenesis and the Clinical Implications

Wang

2022

Eur Neurol

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Pituitary adenomas (PAs) account for the top three primary intracranial tumors in terms of total incidence rate. PAs can cause severe endocrine disorders and even malignant features, such as invasion, metastasis, and recurrence. Therefore, the early diagnosis and accurate prognosis would be greatly beneficial for clinical treatment of PAs. MicroRNAs (miRNAs) are small, protein-noncoding RNAs that regulate gene expression posttranscriptionally. They regulate essential physiological processes, including proliferation, growth, and apoptosis, and also they involve in the invasion and metastasis of malignant tumors. At the tissue level, differential miRNA expression in endocrine malignancies including PAs has been reported. When miRNAs have been successfully detected in various biofluids and cell-free environments, their important roles as potential screening or prognostic biomarkers have been extensively investigated. The current work reviews recent studies on the emerging roles of miRNAs in PAs and the clinical significance.

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Up-regulation of the expressions of MiR-149-5p and MiR-99a-3p in exosome inhibits the progress of pituitary adenomas

Cited by 25 publications

References 57 publications

LncRNA HOXC-AS1 Sponges miR-99a-3p and Upregulates MMP8, Ultimately Promoting Gastric Cancer

LncRNA HOXC-AS1 Sponges miR-99a-3p and Upregulates MMP8, Ultimately Promoting Gastric Cancer

Epithelial–Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly

The Involvement of miRNAs in Pituitary Adenomas Pathogenesis and the Clinical Implications

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