2021
DOI: 10.3389/fmicb.2021.712538
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year. Different glycans on the parasite and the host cell surface play significant roles in both malaria pathogenesis and host defense mechanisms. So far, only small, truncated N- and O-glycans have been identified in Plasmodium species. In contrast, complex glycosylphosphatidylinositol (GPI) glycolipids are highly abundant on the parasite’s cell membrane and are esse… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
7
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 12 publications
(7 citation statements)
references
References 121 publications
0
7
0
Order By: Relevance
“…It has been a matter of debate to what extent Plasmodium species are capable of glycosylating proteins. So far, only short and truncated O - and N -glycans have been identified in Plasmodium blood stage parasites ( 41 ). We showed that TBC2 DM was glycosylated by S2 cells, but whether the short glycans that are attached by S2 cells ( 42 ) impacted the induction of functional antibodies by TBC2 needs to be further investigated.…”
Section: Discussionmentioning
confidence: 99%
“…It has been a matter of debate to what extent Plasmodium species are capable of glycosylating proteins. So far, only short and truncated O - and N -glycans have been identified in Plasmodium blood stage parasites ( 41 ). We showed that TBC2 DM was glycosylated by S2 cells, but whether the short glycans that are attached by S2 cells ( 42 ) impacted the induction of functional antibodies by TBC2 needs to be further investigated.…”
Section: Discussionmentioning
confidence: 99%
“…83 A review on the glycobiology of Plasmodium parasites was recently published. 101 The authors suggested α-gal was an attractive candidate for a transmission blocking vaccine but would not be effective once the disease had taken course. 101 Immunology of the α-gal Epitope in Plasmodium.…”
Section: ■ Glycans In Plasmodiummentioning
confidence: 99%
“…Asexual blood stages of Plasmodium did not bind to the lectin . A review on the glycobiology of Plasmodium parasites was recently published . The authors suggested α-gal was an attractive candidate for a transmission blocking vaccine but would not be effective once the disease had taken course …”
Section: Glycans In Plasmodiummentioning
confidence: 99%
See 1 more Smart Citation
“…Most malaria cases and deaths, 94%, are reported in the African continent [27]. The most vulnerable contingent for this disease is children under five years of age [28].…”
Section: Malariamentioning
confidence: 99%