Unveiling the miRNAs responsive to physical activity/exercise training in cancer: A systematic review

Orlandella, Francesca Maria; Stefano, Anna Elisa De; Braile, Mariantonia; Luciano, Neila; Mancini, Annamaria; Franzese, Monica; Buono, Pasqualina; Salvatore, Giuliana

doi:10.1016/j.critrevonc.2022.103844

Cited by 4 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their altered expression patterns in pancreatic cancer versus controls make them promising diagnostic and prognostic indicators [9,10,[30][31][32][33]. Despite ongoing efforts [34][35][36][37], the roles of miRNA in the etiology and progression of pancreatic cancer are often not fully studied. This is partially attributed to the lengthy and challenging process of determining miRNA functions, which requires reliable target identification through computational predictions and extensive experimental validations.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications

Madadjim,

An,

Cui

2024

IJMS

View full text Add to dashboard Cite

Pancreatic cancer remains a formidable malignancy characterized by high mortality rates, primarily attributable to late-stage diagnosis and a dearth of effective therapeutic interventions. The identification of reliable biomarkers holds paramount importance in enhancing early detection, prognostic evaluation, and targeted treatment modalities. Small non-coding RNAs, particularly microRNAs, have emerged as promising candidates for pancreatic cancer biomarkers in recent years. In this review, we delve into the evolving role of cellular and circulating miRNAs, including exosomal miRNAs, in the diagnosis, prognosis, and therapeutic targeting of pancreatic cancer. Drawing upon the latest research advancements in omics data-driven biomarker discovery, we also perform a case study using public datasets and address commonly identified research discrepancies, challenges, and limitations. Lastly, we discuss analytical approaches that integrate multimodal analyses incorporating clinical and molecular features, presenting new insights into identifying robust miRNA-centric biomarkers.

show abstract

Section: Introductionmentioning

confidence: 99%

MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications

Madadjim,

An,

Cui

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Previous studies focused on the identification of myo-c-miRNAs differently expressed in association with acute and chronic exercise in humans [17,18]. Moreover, these investigations primarily focused on improving health outcomes within different patients, such as those affected by cancer or cardiovascular disorders (CVD) [19,20].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases—A Systematic Review

Afzal,

Greco,

Quinzi

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Exercise may differently affect the expression of key molecular markers, including skeletal muscle and circulating miRNAs, involved in cellular and metabolic pathways’ regulation in healthy individuals and in patients suffering from non-communicable diseases (NCDs). Epigenetic factors are emerging as potential therapeutic biomarkers in the prognosis and treatment of NCDs and important epigenetic factors, miRNAs, play a crucial role in cellular pathways. This systematic review aims to underline the potential link between changes in miRNA expression after different types of physical activity/exercise in some populations affected by NCDs. In June 2023, we systematically investigated the following databases: PubMed, MEDLINE, Scopus, and Web of Science, on the basis of our previously established research questions and following the PRISMA guidelines. The risk of bias and quality assessment were, respectively, covered by ROB2 and the Newcastle Ottawa scale. Of the 1047 records extracted from the initial search, only 29 studies were found to be eligible. In these studies, the authors discuss the association between exercise-modulated miRNAs and NCDs. The NCDs included in the review are cancer, cardiovascular diseases (CVDs), chronic obstructive pulmonary disease (COPD), and type 2 diabetes mellitus (T2DM). We evidenced that miR-146, miR-181, miR-133, miR-21, and miRNA-1 are the most reported miRNAs that are modulated by exercise. Their expression is associated with an improvement in health markers and they may be a potential target in terms of the development of future therapeutic tools.

show abstract

Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review

Nie,

Shaw,

Chen

2023

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

Unveiling the miRNAs responsive to physical activity/exercise training in cancer: A systematic review

Cited by 4 publications

References 71 publications

MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications

MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications

The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases—A Systematic Review

Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review

Contact Info

Product

Resources

About