Unveiling the dermatological potential of marine fungal species components: Antioxidant and inhibitory capacities over tyrosinase

Abstract

Marine fungi are a rich source of biologically active molecules, but a poorly explored bioresource for cosmeceutical products. This study evaluates the phytochemistry, antioxidant, and antityrosinase effects of the organic extracts of marine fungi isolated from various marine environments in India. Out of 35 screened fungal strains, methanol extracts of strains P2, Talaromyces stipitatus, and D4, Aspergillus terreus exhibited antityrosinase activity of 45% and 43%, respectively, at the lowest concentration of 0.5 mg/mL. The highest free radicals scavenging activity of 94% and 97% was observed at 500 mg/mL, respectively, of the same fungal extracts. The total phenolic content ranged from 8.20 to 20.30 mg/g of the dry weight of extract, expressed as gallic acid equivalent. GC-MS analysis of T. stipitatus and A. terreus extract identified seven and 10 major compounds, respectively. Some of the major compounds included azetidine, (3E)-3-[(3,5-dimethoxybenzoyl)hydrazono]-N-isobutyl butanamide, aziridine, and 3methylcyclopentanone, 1,1-dimethylcyclohexane, cyclopentane carboxylic acid, 5,6,, and 3-phenylpropionitrile. In conclusion, this study showed abundant fungal resources in Indian marine environments. A correlation between total phenolic contents of the extracts confirmed that phenolic compounds play an important role in antioxidant as well as antityrosinase activity of the marine fungal extracts and can be viewed as new potential antityrosinase and antioxidant resources.

Hepatoprotective and Antioxidant Potential of Phenolics-Enriched Fraction of Anogeissus acuminata Leaf against Alcohol-Induced Hepatotoxicity in Rats

“…DPPH (DPPH•) is a persistent radical that can accept an electron or hydrogen radical to produce a stable diamagnetic compound, leading to a change in colour. The percentage of DPPH colour change is widely used to estimate radical scavenging efficiency [ 33 , 34 ]. The existence of reducing agents (i.e., antioxidants) enables the Fe 3+ /ferricyanide complex to be reduced to ferrous form.…”

Antibacterial metabolites from an unexplored strain of marine fungiEmericellopsis minimaand determination of the probable mode of action againstStaphylococcus aureusand methicillin‐resistantS. aureus

“…A total of 17 morphologically different fungi was isolated from five samples that were collected from Dwarika using PDA media with natural aged seawater. All 17 fungal strains were subjected to liquid fermentation in potato dextrose broth (PDB; Hi‐Media, Mumbai, India) as described by Agrawal et al., 24 and the dry crude extracts (mixture of methanol extract of fermentation broth and fungal mycelia) were obtained and redissolved in methanol to prepare stock solutions of 1 mg/mL and were kept for biological testing 25 …”

Cosmetic and Pharmaceutic Products with Selected Natural and Synthetic Substances for Melasma Treatment and Methods of Their Analysis

“…At the same time, the literature also reports adverse effects of this type of therapy, which most commonly include skin drying, irritation, peeling, or hypopigmentation [5]. This, in turn, stimulates the search for more natural substitutes and directs researchers' attention toward plant extracts [2,6,7], substances of marine origin [8,9], and even compounds extracted from mushrooms/fungi [10], which show the potential to lighten skin hyperpigmentation.…”