Unusual shape and structure of lymphocyte nuclei is linked to hyperglycemia in type 2 diabetes patients

Martinović, Tamara; Ćirić, Darko; Pantić, Igor; Lalić, Katarina; Rasulić, Iva; Despotović, Sanja; Lalic, I.; Djuricic, D.; Bumbaširević, Vladimir; Kravić-Stevović, Tamara

doi:10.1016/j.tice.2018.04.005

Cited by 11 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies on diabetic patients showed lymphocytic nuclear changes in peripheral blood in the form of irregular contour and more euchromatin. They correlated these changes with the level of blood glucose [32] .…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study between Ginger and Echinacea Possible Effect on the Albino Rat Spleen of Experimentally Induced Diabetes

Said

Abdel-Aziz

Elhaliem

et al. 2020

Egyptian Journal of Histology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

A Comparative Study between Ginger and Echinacea Possible Effect on the Albino Rat Spleen of Experimentally Induced Diabetes

Said

Abdel-Aziz

Elhaliem

et al. 2020

Egyptian Journal of Histology

View full text Add to dashboard Cite

“…Secondly, pathways involved in lipid metabolism play preeminent roles in membrane bending and nuclear invagination genesis, with phosphatidylcholine-related enzyme CCTα being essential for their organization [54][55][56]. Additionally, pathological conditions like diabetes characterized by impairment of lipid metabolism induce nuclear deformation and even pseudo-lobulation in lymphocytes [57]. Thirdly, cholesterol and several up-and down-stream metabolic intermediates are potent signaling molecules [50,[58][59][60][61] and two direct derivatives of the pathway (estradiol and progesterone) have been recently shown to regulate nuclear invagination in endometrial cells [62].…”

Section: The Role Of Cholesterol Biosynthetic Pathway In Nuclear Remomentioning

confidence: 99%

Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton

Martewicz

Luni

Zhu

et al. 2020

Cells

View full text Add to dashboard Cite

Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly understood. Here, we investigate a nucleus-intrinsic mechanism driving nuclear lobulation and segmentation concurrent with granulocyte specification, independently from extracellular forces and cytosolic cytoskeleton contributions. Transcriptomic regulation of cholesterol biosynthesis is equally concurrent with nuclear remodeling. Its putative role as a regulatory element is supported by morphological aberrations observed upon pharmacological impairment of several enzymatic steps of the pathway, most prominently the sterol ∆14-reductase activity of laminB-receptor and protein prenylation. Thus, we support the hypothesis of a nuclear-intrinsic mechanism for nuclear shape control with the putative involvement of the recently discovered GGTase III complex. Such process could be independent from or complementary to the better studied cytoskeleton-based nuclear remodeling essential for cell migration in both physiological and pathological contexts such as immune system function and cancer metastasis.

show abstract

“…In tissue engineering, curvature factors are useful for expressing capacity of cell space filling (or other structure being evaluated) and for evaluating the occurrence of concave or convex irregularities that can be used to perform an accurate analysis of the total area of the structure (Lobo et al, 2016). Solidity is a variable which can be used as a measure of density (Martinovic et al, 2018), in which values close to 1 correspond to a solid structure, while lower values reveal irregular limits, concavities (Soltys et al, 2005). Thus, for seeds with greater solidity, the difference between seed area and the seed convex area reduces, resulting in values of solidity close to 1, which may indicate a well-formed seed without damage.…”

Section: Resultsmentioning

confidence: 99%

Use of radiographic images for rapid and non-destructive assessment of crambe seed quality

et al. 2021

View full text Add to dashboard Cite

Technologies based on electromagnetic radiation, such as the X-ray technique, has contributed to the establishment of new and promising methodologies for evaluating seed quality. This study aimed to relate parameters based on semi-automated analysis of radiographs of crambe seeds to their physiological quality. Radiographic images of seeds from 10 seed lots of cultivar FMS Brilhante were semi-automatically analyzed using ImageJ® software. Measurements of morphometric characteristics and tissue integrity were obtained for the seeds, as well as individually for the seed embryo. Following X-ray test, the seeds were subject to germination and seedling growth test. It was possible to visualize the internal structures of the seeds in the radiographs. There were differences in the physical parameters obtained by the semi-automated analysis of the radiographs between the seed lots. Also, the lots differed regarding the physiological quality of the seeds. Morphometric characteristics and tissue integrity, especially for the seed embryo, showed high correlation with the seed physiological quality. Therefore, this work presents an efficient approach to rapid and non-destructively assess the quality of crambe seeds.

show abstract

Unusual shape and structure of lymphocyte nuclei is linked to hyperglycemia in type 2 diabetes patients

Cited by 11 publications

References 31 publications

A Comparative Study between Ginger and Echinacea Possible Effect on the Albino Rat Spleen of Experimentally Induced Diabetes

A Comparative Study between Ginger and Echinacea Possible Effect on the Albino Rat Spleen of Experimentally Induced Diabetes

Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton

Use of radiographic images for rapid and non-destructive assessment of crambe seed quality

Contact Info

Product

Resources

About