Unusual reaction to chlorambucil in a patient with chronic lymphocytic leukemia

Knisley, R. E.

doi:10.1001/archderm.104.1.77

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2018

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Cited by 8 publications

(2 citation statements)

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“…CADRs induced by chlorambucil are rare, mainly delayed and severe, and present with variable clinical manifestations (Table S1 in File S1) . Among these, pustular features have never previously been reported.…”

Section: Discussionmentioning

confidence: 99%

Systemic delayed hypersensitivity reaction to chlorambucil: a case report and literature review

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Systemic delayed hypersensitivity reaction to chlorambucil: a case report and literature review

et al. 2018

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“…CLB treatment is generally characterized by mild toxicity with bone marrow suppression being the major adverse effect (3). Severe skin hypersensitivity (7) and fever (8) have been observed in CLB‐treated patients. CLB is generally preferred over other alkylating agents in CLL because of its relative lack of important side effects and the less toxic effect on the hematopoietic system (3).…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans organizing pneumonia following chlorambucil treatment for chronic lymphocytic leukemia

Kalambokis¹,

Stefanou

Arkoumani

et al. 2004

European J of Haematology

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A 70-yr-old man developed cough, chest pain, hemoptysis and a pulmonary infiltrate shortly after initiation of treatment with chlorambucil for chronic lymphocytic leukemia. Chlorambucil was discontinued and an open lung procedure was performed with complete excision of the pulmonary lesion. The biopsy specimens showed histological alteration consistent with the diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP). There was no evidence of other known causes usually associated with BOOP. The patient recovered completely after surgery. This report suggests that BOOP must be considered in the differential diagnosis of respiratory symptoms and pulmonary infiltrates in patients treated with chlorambucil.

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