Unusual metastasis of papillary renal cell carcinoma to the pyriform sinus: Case report

Abstract

Renal cell carcinoma is the third most common cause of distant metastasis to the head and neck. Renal cell carcinoma metastasis should be considered in differential diagnosis when patients with a clinical history of renal cell carcinoma show a head and neck mass.

Renal Cell Carcinoma Metastasis to the Hypopharynx: A Case Report

“…Renal cell carcinoma is the ninth most common cancer worldwide and represents 2% to 3% of all malignant tumors in adults. 2 It has a great propensity for metastasis secondary to its hematogenic and vascular access. 3 Renal cell carcinoma is the third most common cause of head and neck metastasis, with the thyroid gland most frequently involved.…”

“…While metastasis of renal cell carcinoma to the head and neck is rare, it should be considered in patients with a history of renal cell carcinoma and head or neck lesions. Renal cell carcinoma is the ninth most common cancer worldwide and represents 2% to 3% of all malignant tumors in adults 2 . It has a great propensity for metastasis secondary to its hematogenic and vascular access 3 .…”

“…Regarding the pharyngo‐laryngeal region, metastatic renal cell carcinoma has been treated in a goal‐oriented fashion to relieve symptoms and improve quality of life through nonsurgical and surgical approaches. While renal cell carcinoma has traditionally been described as a radioresistant tumor, recent reports have shown improving outcomes with radiation therapy, especially in cases of bone and soft‐tissue metastasis 2 . Multiple new immunotherapy agents have also been implemented in the treatment of metastatic renal cell carcinoma with promising perspective.…”

“…While renal cell carcinoma has traditionally been described as a radioresistant tumor, recent reports have shown improving outcomes with radiation therapy, especially in cases of bone and soft-tissue metastasis. 2 Multiple new immunotherapy agents have also been implemented in the treatment of metastatic renal cell carcinoma with promising perspective. Our report is an addition to one of the few cases in the literature of hypopharyngeal metastatic renal cell carcinoma and further highlights the importance of considering metastatic lesions in one's differential diagnosis of dysphagia symptoms.…”

“…1 Renal cell carcinoma is the third most common cause of distant metastasis to the head and neck and should heighten awareness of providers to consider metastasis in their differential diagnosis of head and neck lesions. 2 We report a case of a patient with complaints of dysphagia, with a history of stage IV renal cell carcinoma (with metastasis to the lungs and right adrenal gland), diagnosed as a metastatic mass to the hypopharynx.…”