Unusual local cutaneous reaction to dacarbazine

Serpentine Supravenous Hyperpigmentation Related to Carboplatin and Vinorelbine Chemotherapy: A Case Report

“…It is most commonly seen over the forearm (Geddes, ). Lesions develop within 24 hr to 15 days after intravenous cytotoxic drug infusion and spontaneously transform into residual hyperpigmented bands overlying the venous network within 1–3 weeks; this phase of the eruption is reminiscent of PSHE/SSH (Aydogan, ; Koehn, ; Payne, ). Unlike superficial venous thrombosis or thrombophlebitis, the veins involved in PSEE or PSHE/SSH remain patent (Chan, ; Ghosh, ).…”

“…The eruption may resolve within 1 to few months after termination of chemotherapy, although persistent eruptions have also been reported (Aydogan, ; Chan, ; Payne, ). After repeated intravenous exposure to the responsible drug, the eruption may recur or hyperpigmentation may increase in intensity (Aydogan, ; Chen, ; Fine, ; Koehn, ; Marcoux, ; Spencer, ). In our case, the reaction developed after both the first and second courses of carboplatin and vinorelbine chemotherapy, starting as PSEE and progressing into PSHE/SSH after a few days.…”

Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel

“…Both the terms ‘persistent supravenous erythematous eruption’ (PSEE) and PSSHE are used to describe this type of cutaneous eruption. PSEE is characterized by erythematous streaks or red‐to‐violaceous papules and plaques in the vicinity of the infusion site or following the superficial venous network in a linear or serpentine pattern 2,9–11 . The lesions develop between 24 h and 15 days after intravenous cytotoxic drug infusion and subside spontaneously after 1–3 weeks often leaving residual hyperpigmentation 2 .…”

“…Although these eruptions usually occur at the injection site, serpentine hyperpigmented streaks occurring in areas other than the infusion site have also been reported 4,5 . After repeated intravenous injections of the causative drug, these eruptions may reappear or the hyperpigmentation may increase 2,3,9 . To prevent confusion, the term ‘persistent serpentine supravenous hyperpigmented eruption’ seems appropriate to describe this group of cutaneous eruptions, which begin as erythematous serpentine streaks over the injected veins and are soon replaced by hyperpigmentation, which persists for a long time.…”

Persistent supravenous eruption induced by intravenous bortezomib therapy

“…The classic offending cytotoxic drug is 5‐fluorouricil 4,7 . However, previous literature reviews have also reported this reaction after administration of docetaxel, 5 vinorelbine, 8 nitrosourea fotemustine, 9 broxuridine, dacarbazine, 10 and a combination of actinomycin and vincristine 6 …”