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“…Nevertheless, UDP-glucose induces HA synthesis in keratinocytes via P2Y14 receptor, STAT3 signaling and activation of hyaluronan synthase (HAS) promoter (Jokela et al, 2014). The conformation of HA in solution is readily subjected to changes upon altering the compositions of solvents, and this affects the functional properties of HA in many biological processes such as interactions with complement proteins and their associated hemolytic function (Chang and Boackle, 1985; Chang et al, 1985; Hong et al, 2007b). For example, under low ionic strength conditions, HA has a less compact conformation in the saliva that allows its interactions with complement proteins and bacteria (Chang and Boackle, 1986).…”
Section: Introductionmentioning
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“…Nevertheless, UDP-glucose induces HA synthesis in keratinocytes via P2Y14 receptor, STAT3 signaling and activation of hyaluronan synthase (HAS) promoter (Jokela et al, 2014). The conformation of HA in solution is readily subjected to changes upon altering the compositions of solvents, and this affects the functional properties of HA in many biological processes such as interactions with complement proteins and their associated hemolytic function (Chang and Boackle, 1985; Chang et al, 1985; Hong et al, 2007b). For example, under low ionic strength conditions, HA has a less compact conformation in the saliva that allows its interactions with complement proteins and bacteria (Chang and Boackle, 1986).…”
Section: Introductionmentioning
“…For example, HA chains at different length scales can adopt different conformational states—extended, condensed, and relaxed—which are dependent upon pH, temperature, and salt concentration ( 151 ). Small changes in the local environment readily alter the conformation of HA and this was shown to affect the role of the GAG in biological processes such as the interaction with the complement system ( 152 154 ). Furthermore, the different preferences of short and long HA chains to involve in intermolecular interactions to form aggregates further expand the variety of molecular shapes of HA ( 155 ).…”
Section: Size Matters—ha At Different Sizesmentioning