Unusual association of Eales disease with multifocal neurological deficit

Abstract

A man who had suffered from Eales disease at the age of 20 presented an acute Brown-Séquard spinal syndrome when he was 30, followed shortly after by paralysis of the right abducens and recurrent laryngeal nerves. Steroid treatment apparently relieved the myelopathy while the neurological deficits have remained unchanged for the past 14 years. In view of the clinical and CSF findings the neurological deficits are attributed to the same disease process as that underlying the peripheral retinal abnormalities characteristic of Eales disease rather than to multiple sclerosis.

Mycobacterium tuberculosisInfection Complicated by Eales Disease with Peripheral Neuropathy

“…In our patient, there was a dramatic response that was consistent with suppression of an acute inflammatory process. Similar success has been reported by others [12]. However, in one series, the response was mixed, although the patients in that study varied widely with regard to the time between the onset of symptoms and the institution of corticosteroid therapy [11].…”

Steroid-responsive painful ophthalmoplegia: Tolosa–Hunt syndrome, Eales disease, or both?

“…Neurological causes are the most common extra-ocular manifestations. These include myelitis or myelopathy (5,7–9), stroke (5,10–12), internuclear ophthalmoplegia (13), ataxia (9), peripheral neuropathy (14) and cranial nerve paralysis (15). The neurological manifestations of ED are usually responsive to steroids and the ophthalmological symptoms precede neurological symptoms in more than 50% of patients by a period of six months to 10 years (5).…”