Untargeted serum and liver metabolomics analyses reveal the gastroprotective effect of polysaccharide from Evodiae fructus on ethanol-induced gastric ulcer in mice

Anti-Bordetella bronchiseptica effects of targeted bacteriophages via microbiome and metabolic mediated mechanisms

“…Comprehensive metabolomics provides information on body metabolic state and how that status varies in various environmental circumstances 20 , 42 . Therefore, the enriched metabolism pathways in the PC, BN, and AT treatments may give further information about pigs requirements, which can be supplemented in their diets to reduce the adverse side effects of B. bronchiseptica infection.…”

“…Ascorbate is also important for the synthesis of neurotransmitters, such as norepinephrine and dopamine, and for the metabolism of iron 46 , 47 . Moreover, aldarate is a type of sugar that is involved in the metabolism of carbohydrates 18 , 20 . It is produced during the breakdown of carbohydrates, and it is also involved in the synthesis of certain lipids and the metabolism of certain amino acids 20 .…”

“…Moreover, aldarate is a type of sugar that is involved in the metabolism of carbohydrates 18 , 20 . It is produced during the breakdown of carbohydrates, and it is also involved in the synthesis of certain lipids and the metabolism of certain amino acids 20 . Ascorbate and aldarate are both important for maintaining the overall health and functioning of the pigs.…”

“…The treatment with bacteriophages or antibiotics can affect the body metabolic pathways due to the change in the microbiome and immune status 17 , potentially serving as a marker for assessing pigs nutritional requirements. Blood functional metabolomics is the study of small molecule metabolites in blood, which can provide insights into the metabolic processes and functional states of various biological systems, including the immune system 18 – 20 . The metabolites in the blood can reflect changes in the immune system, and their levels can be influenced by nutrition and diet 21 .…”

Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods

“…Liquid chromatography–ion trap–time-of-flight/mass spectrometry (LC-IT-TOF/MS) can be used to assess numerous non-target metabolic characteristics, particularly for solving the problems of primary metabolism, complex secondary metabolites, and large plant systems. In fact, there have been many studies on the mechanisms underlying the pharmacological activities of Euodia alkaloids based on metabolomics technology [ 21 , 22 , 23 , 24 ]. In recent years, the field of metabolomics has gained significant traction as a valuable analytical tool for optimizing the potential health benefits of underutilized medicinal plants and associated substances.…”