Untacking small RNA profiling and RNA fragment footprinting: Approaches and challenges in library construction
Zhaokang Shen,
Muhammad Naveed,
Jianqiang Bao
Abstract:Small RNAs (sRNAs) with sizes ranging from 15 to 50 nucleotides (nt) are critical regulators of gene expression control. Prior studies have shown that sRNAs are involved in a broad range of biological processes, such as organ development, tumorigenesis, and epigenomic regulation; however, emerging evidence unveils a hidden layer of diversity and complexity of endogenously encoded sRNAs profile in eukaryotic organisms, including novel types of sRNAs and the previously unknown post‐transcriptional RNA modificati… Show more
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