2018
DOI: 10.18632/aging.101412
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Abstract: The inflammatory cascade can be initiated with the recognition of damaged DNA. Macrophages play an essential role in particulate matter (PM)-induced airway inflammation. In this study, we aim to explore the PM induced DNA damage response of macrophages and its function in airway inflammation. The DNA damage response and inflammatory response were assessed using bone marrow–derived macrophages following PM treatment and mouse model instilled intratracheally with PM. We found that PM induced significant DNA dama… Show more

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Cited by 6 publications
(4 citation statements)
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References 46 publications
(48 reference statements)
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“…Consequently, impairment of DNA damage repair mechanisms may lead to DNA damage accumulation, thus explaining the increased NR8383 cell death detected by LDH assay following exposure to pristine MWCNT NM403 [62]. Previous studies have indicated that DNA damage [63] and cell death [64] contribute to inflammatory response. Additionally, our analysis indicated that interferons, which are known to be involved in DNA damage [65] and the induction of inflammatory response [66], were dysregulated following exposure to the pristine MWCNT NM403.…”
Section: Functionalization-dependent Mechanisms Toxicity Mechanism Ofmentioning
confidence: 99%
“…Consequently, impairment of DNA damage repair mechanisms may lead to DNA damage accumulation, thus explaining the increased NR8383 cell death detected by LDH assay following exposure to pristine MWCNT NM403 [62]. Previous studies have indicated that DNA damage [63] and cell death [64] contribute to inflammatory response. Additionally, our analysis indicated that interferons, which are known to be involved in DNA damage [65] and the induction of inflammatory response [66], were dysregulated following exposure to the pristine MWCNT NM403.…”
Section: Functionalization-dependent Mechanisms Toxicity Mechanism Ofmentioning
confidence: 99%
“…The treatment of cells with MM compounds resulted in a substantial heterogeneity of DNA damage, with values ranging from 0 to 100% tail DNA in the samples, which is consistent with the results obtained by other authors. This matter of producing 100% of tail DNA % can be attributed to some sort of bias using the software or the quality of the obtained images [ 21 , 22 ]. The occurrence of comets with >90% of DNA in the tail in the negative control samples could be attributed to the apoptosis of single cells and is a natural phenomenon, resulting, for example, from the preparation of samples.…”
Section: Resultsmentioning
confidence: 99%
“…The PM used in this study is Standard Reference Material (SRM) 1649b. SRM 1649b was purchased from the National Institutes of Technology (Gaithersburg, MD, USA) [ 21 ]. PM was suspended and sonicated in sterile saline to a final concentration at 2 mg/ml.…”
Section: Methodsmentioning
confidence: 99%