Unravelling the Olfactory Sense: From the Gene to Odor Perception

Teixeira, Carla S. Silva; Cerqueira, Nuno M. F. S. A.; Ferreira, António César Silva

doi:10.1093/chemse/bjv075

Cited by 42 publications

(46 citation statements)

References 170 publications

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“…Our simplified model neglects many details of the olfactory system [17]. For instance, we do not consider the dynamics of inhalation and the odor absorption in the mucus [72, 73].…”

Section: Discussionmentioning

confidence: 99%

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Normalized Neural Representations of Complex Odors

Zwicker

2016

PLoS ONE

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The olfactory system removes correlations in natural odors using a network of inhibitory neurons in the olfactory bulb. It has been proposed that this network integrates the response from all olfactory receptors and inhibits them equally. However, how such global inhibition influences the neural representations of odors is unclear. Here, we study a simple statistical model of the processing in the olfactory bulb, which leads to concentration-invariant, sparse representations of the odor composition. We show that the inhibition strength can be tuned to obtain sparse representations that are still useful to discriminate odors that vary in relative concentration, size, and composition. The model reveals two generic consequences of global inhibition: (i) odors with many molecular species are more difficult to discriminate and (ii) receptor arrays with heterogeneous sensitivities perform badly. Comparing these predictions to experiments will help us to understand the role of global inhibition in shaping normalized odor representations in the olfactory bulb.

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“…Our simplified model neglects many details of the olfactory system [17]. For instance, we do not consider the dynamics of inhalation and the odor absorption in the mucus [72, 73].…”

Section: Discussionmentioning

confidence: 99%

“…In this paper, we study a simple model of the olfactory system that resembles its first processing layers, which transform the odor representation successively [16, 17], see Fig 1. Our model connects previous results from simulations of the neural circuits [18–23] to system-level descriptions of the olfactory system [24–27].…”

Section: Introductionmentioning

confidence: 99%

Normalized Neural Representations of Complex Odors

Zwicker

2016

PLoS ONE

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“…The study of aroma and aroma perception is in its infancy, but is of increasing interest to science as well as the perfume and food industries (Silva Teixeira, Cerqueira et al 2016). Aromas arise largely from the volatilization of chemicals that are then perceived by olfactory receptors in the nares (Buck and Axel 1991) and are a point of emphasis in marketing, highlighting their economic importance.…”

Section: Introductionmentioning

confidence: 99%

Models of toxicity of diacetyl and alternative diones

Brass

Palmer

2017

Toxicology

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Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH3CO)2 is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient. However, because of this increased occupational use, workers can be exposed to high vapor concentrations in the workplace. Despite being listed by the USFDA to be ‘generally regarded as safe’ (GRAS), multiple lines of evidence suggest that exposure to high concentrations of DA vapor causes long-term impairments in lung function with lung function testing indicating evidence of either restrictive or obstructive airway narrowing in affected individuals. A growing number of preclinical studies have now addressed the short and long-term toxicity associated with DA exposure providing further insight into the toxicity of DA and related diones. This review summarizes these observations.

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“…7 cm along the nasal cavities and its area is approx. 1.52.5 cm 2 [1]. Sensory cells are grouped in bundles which go on both sides through the cribriform plate located in the anterior cranial fossa.…”

Section: Overview Of Neuroanatomy Structures Associated With the Olfamentioning

confidence: 99%

“…area olfactoria), która zawiera nabłonek węchowy (olfactory epithelium). Jest on zlokalizowany w jamach nosowych na długości ok. 7 cm i zajmuje ok. 1,5-2,5 cm 2 [1]. Komórki sensoryczne są zgrupowane w wiązki, któ re przechodzą dwustronnie przez płytkę kostną zwaną blaszką sitową (cribriform plate), znajdującą się w przed nim dole czaszki (anterior cranial fossa).…”

Section: Omówienie Struktur Neuroanatomicznych Związanych Z Funkcjonounclassified

Olfactory dysfunctions occurring in the course of Parkinson’s disease

Śmigórski¹,

Śmigórska²

2017

ppn

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Purpose: The aim of this article is to provide a summary of findings concerning the olfactory loss associated with pathological neuro degenerative changes which occur in the course of Parkinson's disease. Views: Olfactory function deficits occur in the early, prodromal stage of Parkinson's disease and their severity is much higher, especially compared with other neurodegenerative diseases. Information on characteristics of olfactory loss in Parkinson's disease is presented in the article. Conclusions: Authors indicate that olfactory function assessment is useful in differential diagnosis of neurodegenerative disorders in their prodromal stage and physiological aging. Olfactory ability evaluation may be also very helpful in differential diagnosis of parkinsonism syndromes. Severity of the olfactory impairment may be a good predictor of neuropsychiatric complications de velopment in Parkinson's disease. Key words: Parkinson's disease, olfaction disorders, olfactory perception, dementia, smell. StreszczenieCel: Celem artykułu jest przedstawienie stanu wiedzy na temat utraty sprawności węchowej związanej z patologicznymi zmianami neurozwyrodnieniowymi zachodzącymi w przebiegu choroby Parkinsona. Poglądy: Zaburzenia sprawności węchowej pojawiają się we wczesnym, prodromalnym etapie rozwoju choroby Parkinsona, a ich natężenie jest większe niż w innych chorobach neurozwyrodnieniowych. W artykule przedstawiono informacje na temat charakte rystyki utraty węchu w chorobie Parkinsona.Wnioski: Autorzy wykazują, że ocena sprawności węchowej jest użyteczna w różnicowaniu zaburzeń neurozwyrodnieniowych w ich prodromalnym stadium z fizjologicznym starzeniem się. Ewaluacja sprawności węchowej może być również bardzo pomocna w róż nicowaniu diagnostycznym zespołów parkinsonowskich. Głębokość zaburzeń węchowych może być dobrym predyktorem rozwoju zaburzeń neuropsychiatrycznych w chorobie Parkinsona. Słowa kluczowe: choroba Parkinsona, zaburzenia węchu, percepcja węchowa, otępienie, węch.

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Unravelling the Olfactory Sense: From the Gene to Odor Perception

Cited by 42 publications

References 170 publications

Normalized Neural Representations of Complex Odors

Normalized Neural Representations of Complex Odors

Models of toxicity of diacetyl and alternative diones

Olfactory dysfunctions occurring in the course of Parkinson’s disease

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