Unravelling the involvement of gut microbiota in type 2 diabetes mellitus

Arora, Aashima; Behl, Tapan; Sehgal, Aayush; Singh, Sukhbir; Sharma, Neelam; Bhatia, Saurabh; Sobarzo‐Sánchez, Eduardo; Bungău, Simona

doi:10.1016/j.lfs.2021.119311

Cited by 87 publications

(55 citation statements)

References 172 publications

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“…It will be necessary to compare not only the effects of long-term excess HFCS intake, but also the effects of other sweeteners, such as sucrose, and of conditions that do not restrict energy intake, in future research. Recently, it has become clear that the microbiome influences inflammation, obesity, metabolic disease, and metabolic functions [ 66 , 67 ]. Excess HFCS intake during a short term of adolescence in mice induces fatty liver, alters metabolic pathways, many of which are also altered in adulthood, and changes the microbiome [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

et al. 2021

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The number of patients with diabetes was approximately 463 million worldwide in 2019, with almost 57.6% of this population concentrated in Asia. Asians often develop type 2 diabetes (T2D), even if they are underweight and consume a smaller amount of food. Soft drinks contain large amounts of sweeteners, such as high-fructose corn syrup (HFCS). Excessive intake of HFCS drinks is considered to be one of the causes of T2D. In the present study, we investigated the effect of excessive consumption of HFCS–water on glucose tolerance and obesity under conditions of controlled caloric intake using a mouse model. Three-week-old male ICR mice were divided into two groups and given free access to 10% HFCS–water or deionized water. The caloric intake was adjusted to be the same in both groups using a standard rodent diet. The excess HFCS–water intake did not lead to obesity, but led to impaired glucose tolerance (IGT) due to insulin-secretion defect. It affected glucose and fructose metabolism; for example, it decreased the expression of glucokinases, ketohexokinase, and glucose transporter 2 in the pancreas. These results suggest that excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect.

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Section: Discussionmentioning

confidence: 99%

Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

et al. 2021

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“…In recent years, a line of evidences has demonstrated that diabetes is closely related to the imbalance of intestinal microbes ( Arora et al, 2021 ). As early as 2007, it was reported that sterile mice were less likely to be obese than ordinary mice even if they were fed with HFD ( Backhed et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Glucosamine Ameliorates Symptoms of High-Fat Diet-Fed Mice by Reversing Imbalanced Gut Microbiota

et al. 2021

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Glucosamine (GlcN) is used as a supplement for arthritis and joint pain and has been proved to have effects on inflammation, cancer, and cardiovascular diseases. However, there are limited studies on the regulatory mechanism of GlcN against glucose and lipid metabolism disorder. In this study, we treated high-fat diet (HFD)-induced diabetic mice with GlcN (1 mg/ml, in drinking water) for five months. The results show that GlcN significantly reduced the fasting blood glucose of HFD-fed mice and improved glucose tolerance. The feces of intestinal contents in mice were analyzed using 16s rDNA sequencing. It was indicated that GlcN reversed the imbalanced gut microbiota in HFD-fed mice. Based on the PICRUSt assay, the signaling pathways of glucolipid metabolism and biosynthesis were changed in mice with HFD feeding. By quantitative real-time PCR (qPCR) and hematoxylin and eosin (H&E) staining, it was demonstrated that GlcN not only inhibited the inflammatory responses of colon and white adipose tissues, but also improved the intestinal barrier damage of HFD-fed mice. Finally, the correlation analysis suggests the most significantly changed intestinal bacteria were positively or negatively related to the occurrence of inflammation in the colon and fat tissues of HFD-fed mice. In summary, our studies provide a theoretical basis for the potential application of GlcN to glucolipid metabolism disorder through the regulation of gut microbiota.

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“…Emerging research assessed the correlation between A. muciniphila intestinal abundance and human body weight. There are proofs that these two variables have an opposite correlation [142,143]. The numbers of Bifidobacterium spp.…”

Section: A Muciniphila and Obesity: Evidence From Human Studiesmentioning

confidence: 99%

Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium

et al. 2021

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Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) are diseases that can be influenced by the structure of gut microbiota, whose improvement is often neglected in metabolic pathology. This review highlights the following main aspects: the relationship between probiotics/gut microbes with the pathogenesis of MetS, the particular positive roles of Akkermansia muciniphila supplementation in the onset of MetS, and the interaction between dietary polyphenols (prebiotics) with gut microbiota. Therefore, an extensive and in-depth analysis of the often-neglected correlation between gut microbiota and chronic metabolic diseases was conducted, considering that this topic continues to fascinate and stimulate researchers through the discovery of novel strains and their beneficial properties.

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Unravelling the involvement of gut microbiota in type 2 diabetes mellitus

Cited by 87 publications

References 172 publications

Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

Glucosamine Ameliorates Symptoms of High-Fat Diet-Fed Mice by Reversing Imbalanced Gut Microbiota

Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium

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