Unravelling cardiovascular disease using four dimensional flow cardiovascular magnetic resonance

Kamphuis, Vivian P.; Westenberg, Jos J.M.; Palen, Roel L.F. van der; Blom, Nico A.; Roos, Albert de; Geest, Rob J. van der; Elbaz, Mohammed; Roest, Arno A.W.

doi:10.1007/s10554-016-1031-9

Cited by 30 publications

(26 citation statements)

References 99 publications

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“…Further advances in research of aortic hemodynamic were achieved by introducing three-and four-(time resolved)dimensional flow MRI [22]. In the recent flow-sensitive MRI studies, the pattern of aortic flow has been shown directly, which confirmed the above-mentioned observations.…”

Section: Discussionsupporting

confidence: 57%

The impact of the aortic cusps fusion pattern and valve disease severity on the aortic wall mechanics in patients with bicuspid aortic valve

Kalinowski

Szulik

Pawlak

et al. 2020

Int J Cardiovasc Imaging

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The ascending aorta dilatation in the bicuspid aortic valve (BAV) patients is often attributed to congenital abnormalities of the aortic wall, but it may be related to hemodynamic disturbances in the course of BAV disease. At present, ascending aortic diameter is used as almost sole but weak predictor of aortic dissection and rupture in BAV. We examined the association between aortic wall mechanics and severity of aortic valve disease including different cusps fusion patterns using conventional echocardiography and tissue Doppler imaging (TDI). We prospectively studied 106 BAV patients: 72 with right-left (R-L) coronary cusp fusion were matched 1:1 to 34 patients with right-noncoronary (R-N) cusp fusion obtaining 34 pairs of patients. Peak systolic radial velocity and acceleration of the ascending aortic wall, measured by TDI, were used as an index of hemodynamic stress imposed on the aorta. Paired analysis showed higher aortic wall radial velocity (4.71 ± 1.61 cm/s vs. 3.33 ± 1.44 cm/s, p = 0.001) and acceleration (1.08 ± 0.46 m/s 2 vs. 0.80 ± 0.34 m/s 2 , p = 0.

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Section: Discussionsupporting

confidence: 57%

The impact of the aortic cusps fusion pattern and valve disease severity on the aortic wall mechanics in patients with bicuspid aortic valve

Kalinowski

Szulik

Pawlak

et al. 2020

Int J Cardiovasc Imaging

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“…Four-dimensional flow magnetic resonance imaging (4D flow MRI) is a non-invasive imaging method to investigate in vivo cardiovascular flow and is used to better understand cardiovascular physiology and pathophysiology. Besides simple measures of flow [ 1 – 3 ], this technique allows for quantification of more comprehensive hemodynamic parameters, such as wall shear stress (WSS) [ 4 , 5 ]. WSS is defined as the viscous shear force of flowing blood acting tangentially to the vessel wall and can be estimated in both small and large vessels.…”

Section: Introductionmentioning

confidence: 99%

Scan–rescan reproducibility of segmental aortic wall shear stress as assessed by phase-specific segmentation with 4D flow MRI in healthy volunteers

Palen

Roest

Boogaard

et al. 2018

Magn Reson Mater Phy

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ObjectiveThe aim was to investigate scan–rescan reproducibility and observer variability of segmental aortic 3D systolic wall shear stress (WSS) by phase-specific segmentation with 4D flow MRI in healthy volunteers.Materials and methodsTen healthy volunteers (age 26.5 ± 2.6 years) underwent aortic 4D flow MRI twice. Maximum 3D systolic WSS (WSSmax) and mean 3D systolic WSS (WSSmean) for five thoracic aortic segments over five systolic cardiac phases by phase-specific segmentations were calculated. Scan–rescan analysis and observer reproducibility analysis were performed.ResultsScan–rescan data showed overall good reproducibility for WSSmean (coefficient of variation, COV 10–15%) with moderate-to-strong intraclass correlation coefficient (ICC 0.63–0.89). The variability in WSSmax was high (COV 16–31%) with moderate-to-good ICC (0.55–0.79) for different aortic segments. Intra- and interobserver reproducibility was good-to-excellent for regional aortic WSSmax (ICC ≥ 0.78; COV ≤ 17%) and strong-to-excellent for WSSmean (ICC ≥ 0.86; COV ≤ 11%). In general, ascending aortic segments showed more WSSmax/WSSmean variability compared to aortic arch or descending aortic segments for scan–rescan, intraobserver and interobserver comparison.ConclusionsScan–rescan reproducibility was good for WSSmean and moderate for WSSmax for all thoracic aortic segments over multiple systolic phases in healthy volunteers. Intra/interobserver reproducibility for segmental WSS assessment was good-to-excellent. Variability of WSSmax is higher and should be taken into account in case of individual follow-up or in comparative rest–stress studies to avoid misinterpretation.Electronic supplementary materialThe online version of this article (10.1007/s10334-018-0688-6) contains supplementary material, which is available to authorized users.

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“…In July 2017 the Topical issue on Emerging concepts on Invasive and Noninvasive Coronary Physiological Assessment was published with a great overview over the various imaging modalities with a total of 15 scientific papers by the experts in this field on invasive and non-invasive flow reserve, flow-pressure relationships, microvascular dysfunction, perfusion imaging and wall shear stress [94][95][96][97][98][99][100][101][102][103][104][105][106][107][108].…”

Section: Topical Issue On Emerging Concepts On Invasive and Noninvasimentioning

confidence: 99%

Cardiovascular imaging 2017 in the International Journal of Cardiovascular Imaging

Reiber

Alaiti

Bezerra

et al. 2018

Int J Cardiovasc Imaging

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Unravelling cardiovascular disease using four dimensional flow cardiovascular magnetic resonance

Cited by 30 publications

References 99 publications

The impact of the aortic cusps fusion pattern and valve disease severity on the aortic wall mechanics in patients with bicuspid aortic valve

The impact of the aortic cusps fusion pattern and valve disease severity on the aortic wall mechanics in patients with bicuspid aortic valve

Scan–rescan reproducibility of segmental aortic wall shear stress as assessed by phase-specific segmentation with 4D flow MRI in healthy volunteers

Cardiovascular imaging 2017 in the International Journal of Cardiovascular Imaging

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