2019
DOI: 10.1111/apa.15102
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Abstract: Preterm infants are at increased risk of extrauterine growth restriction, which at least in part is caused by very high extrauterine nutritional needs. 1 In addition, the inability to assimilate sufficient nutrition due to feeding intolerance secondary to immaturity and neonatal morbidities is especially common in extremely preterm infants. The result is significant energy and protein deficits, primarily in the early postnatal period. 2 Most extremely preterm neonates suffer from growth restriction that can pe… Show more

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Cited by 9 publications
(9 citation statements)
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“…Our data showed for the first time that feeding donated breast milk to isolated newborn piglets compensates very early for deficits in postnatal lung maturation. This is in line with a very recent study showing unpasteurized breast milk to be positively associated with growth outcomes in extremely premature infants (47). Breast milk stimulates the proliferation of a balanced and diverse intestinal microbiota, which initially influences a switch from an intrauterine Th2-dominant to a Th1/Th2-balanced response and induces activation of Treg cells by breast milk-stimulated specific organisms (Bifidobacteria, Lactobacillus, and Bacteroides) (48).…”
Section: Discussionsupporting
confidence: 86%
“…Our data showed for the first time that feeding donated breast milk to isolated newborn piglets compensates very early for deficits in postnatal lung maturation. This is in line with a very recent study showing unpasteurized breast milk to be positively associated with growth outcomes in extremely premature infants (47). Breast milk stimulates the proliferation of a balanced and diverse intestinal microbiota, which initially influences a switch from an intrauterine Th2-dominant to a Th1/Th2-balanced response and induces activation of Treg cells by breast milk-stimulated specific organisms (Bifidobacteria, Lactobacillus, and Bacteroides) (48).…”
Section: Discussionsupporting
confidence: 86%
“…Out of the 138 infants born at GA <28 weeks during the inclusion period, parents/legal guardians of 90 eligible infants agreed to participate after informed consent. Details of the nutritional strategy and nutritional data collection have been described in detail ( Najm et al, 2017 ; Lund et al, 2020 ). Growth data (weight, length, and head circumference) were prospectively collected until term equivalent age and transformed into z-scores according to the growth reference by Niklasson and Albertsson-Wikland (2008) .…”
Section: Methodsmentioning
confidence: 99%
“…Therefore, an infant’s metabolic profile depends on the GA and the postnatal age ( Clark et al, 2014 ). Furthermore, the feeding regime influences the growth trajectory for the preterm infant ( Power et al, 2019 ; Lund et al, 2020 ; Roggero et al, 2020 ), and poor growth gain during the 1st weeks of life is predictive for adverse morbidity outcomes, including severe ROP and BPD ( Hellström et al, 2010 ; Chisholm et al, 2019 ).…”
Section: Introductionmentioning
confidence: 99%
“…Individualized fortification based on breast milk analysis of energy and macronutrient content was practiced for both maternal and donor milk. The enteral nutrition protocol has been described in more detail elsewhere [26]. Data regarding nutritional intake were collected prospectively during the first 28 days of hospitalization.…”
Section: Nutritional Management and Collection Of Nutritional Datamentioning
confidence: 99%
“…Potential nutrients from blood products were not included in the data analysis. A more detailed description regarding the collection of nutritional data in this cohort was reported previously [26].…”
Section: Nutritional Management and Collection Of Nutritional Datamentioning
confidence: 99%