Unorthodox long‐term aerosolized ampicillin use for methicillin‐susceptible <i>Staphylococcus aureus</i> lung infection in a cystic fibrosis patient

Máiz, Luís; Lamas, Adelaida; Fernández-Olmos, Ana; Suárez, L.

doi:10.1002/ppul.20983

Cited by 11 publications

(2 citation statements)

References 21 publications

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“…In February 2007, due to frequent PE and rapid LF decline, she was started on aerosolized ampicillin (Gobemicina®, Normon Laboratories, Madrid, Spain) every 12 hours. As previously reported [21], the response to this treatment was excellent for a year. On February 2008 she again suffered severe and frequent PE, even while on aerosolized ampicillin, and always related to menstrual cycle as described above.…”

Section: Case Presentationsupporting

confidence: 79%

Subcutaneous implant with etonogestrel (Implanon®) for catamenial exacerbations in a patient with cystic fibrosis: a case report

et al. 2014

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BackgroundCystic Fibrosis (CF) is a genetic disease with equal prevalence across sexes. However, women present worse lung function with faster function decline, earlier onset of bacterial colonization, more frequent pulmonary exacerbations (PE), greater bronchial hyper-responsiveness, and higher mortality rates after puberty than men. The etiology of this gender disparity remains elusive but female hormones have been implicated in several studies.Case presentationA 20-year-old female with CF with severe recurrent PE, always related to the menstrual cycle since menarche, combined with lung function decline requiring multiple courses of intravenous antibiotics. We report the cessation of PE and recovery of pulmonary function following the insertion of a subcutaneous implant with 68 mg of etonogestrel (Implanon®, Organon Española S.A. Laboratories, Madrid, Spain).ConclusionOur case report supports the key role of female hormones in the development of PE and in the decline of lung function in a woman with CF. When appropriate, hormonal manipulation through contraceptive methods should be considered as potential treatment.

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Section: Case Presentationsupporting

confidence: 79%

Subcutaneous implant with etonogestrel (Implanon®) for catamenial exacerbations in a patient with cystic fibrosis: a case report

et al. 2014

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“…One case report reported a successful long-term aerosolised ampicillin treatment of a 14-year-old girl with chronic symptomatic S aureus lung infection (Máiz 2009).…”

Section: Agreements and Disagreements With Other Studies Or Reviewsmentioning

confidence: 99%

Treatment for chronic methicillin-sensitiveStaphylococcus aureuspulmonary infection in people with cystic fibrosis

Ahmed

Mukherjee

2018

Cochrane Database of Systematic Reviews

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Treatment for chronic methicillin-sensitiveStaphylococcus aureuspulmonary infection in people with cystic fibrosis

Ahmed

Mukherjee

2016

Cochrane Database of Systematic Reviews

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No randomised controlled trials were identified which met the inclusion criteria for this review. Although methicillin-sensitive Staphylococcus aureus is an important and common cause of lung infection in people with cystic fibrosis, there is no agreement on how best to treat long-term infection. The review highlights the need to organise well-designed trials that can provide evidence to support the best management strategy for chronic methicillin-sensitive Staphylococcus aureus infection in people with cystic fibrosis.

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Unorthodox long‐term aerosolized ampicillin use for methicillin‐susceptible Staphylococcus aureus lung infection in a cystic fibrosis patient

Cited by 11 publications

References 21 publications

Subcutaneous implant with etonogestrel (Implanon®) for catamenial exacerbations in a patient with cystic fibrosis: a case report

Subcutaneous implant with etonogestrel (Implanon®) for catamenial exacerbations in a patient with cystic fibrosis: a case report

Treatment for chronic methicillin-sensitiveStaphylococcus aureuspulmonary infection in people with cystic fibrosis

Treatment for chronic methicillin-sensitiveStaphylococcus aureuspulmonary infection in people with cystic fibrosis

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