Unmasking Uremic Encephalopathy: Choreoathetoid Movements Mimicking Alcohol Withdrawal in a Person with an Alcohol Use Disorder

Abstract

Chorea is a disorder characterized by irregular, involuntary movements affecting the limbs, trunk, neck, or face. It can be a significant symptom in various neurologic diseases, including metabolic, autoimmune, and neurodegenerative conditions. The neural foundation that underlies the genesis of chorea appears to be fairly diverse, even though its pathophysiology is frequently associated with the malfunctioning of inhibitory circuits within the basal ganglia. Movement disorders such as tremors, myoclonus, ataxia, chorea, and Parkinsonism may arise due to renal dysfunction or complications from management like renal transplant and hemodialysis. Uremic encephalopathy is a rare but potentially life-threatening neurological complication of chronic kidney disease.We present a case of a 50-year-old male with a known history of chronic kidney disease and chronic alcoholism, who exhibited abnormal movements resembling chorea upon presentation. Initially suspected as alcohol withdrawal-related chorea, further evaluation revealed concurrent rising creatinine levels, acidosis, and hyperkalemia. Hemodialysis was initiated, resulting in a significant improvement in choreoathetoid movements. This case implies the importance of considering uremic encephalopathy in the differential diagnosis of movement disorders in patients with underlying kidney dysfunction, even in the context of chronic alcoholism.

Metronidazole-Induced Acute Cerebellitis in a Young Patient: Unusual Onset, Delayed Remission, and Characteristic Imaging Features

“…Cerebellar dysfunction, particularly ataxia (other causes of ataxia) and dysarthria, is the most prevalent presentation among patients affected with metronidazole-induced cerebellitis [8][9][10]. With prolonged selfmedication drug use in this particular patient, the problem emerged shortly after initiating metronidazole treatment.…”