Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats

Ahmed, Hanan H.; Essam, Reham M.; El-Yamany, Muhammed F.; Ahmed, Kawkab A.; El-Sahar, Ayman E.

doi:10.1039/d3fo02222f

Food Funct.

2023

DOI: 10.1039/d3fo02222f

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Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats

Hanan H. Ahmed,

Reham M. Essam,

Muhammed F. El-Yamany

et al.

Abstract: The effects of CRS on inducing depression and the beneficial effect of LF in halting depression through mitigating ROS and pro-inflammatory cytokines, restoring corticosterone, 5-HT and BDNF levels, and modulating the hippocampal PI3K/Akt/mTOR/GSK-3β pathway were studied.

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Cited by 6 publications

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Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats

Abstract: The effects of CRS on inducing depression and the beneficial effect of LF in halting depression through mitigating ROS and pro-inflammatory cytokines, restoring corticosterone, 5-HT and BDNF levels, and modulating the hippocampal PI3K/Akt/mTOR/GSK-3β pathway were studied.

Cited by 6 publications

References 74 publications

New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD)

New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD)

Unlocking the power of Lactoferrin: Exploring its role in early life and its preventive potential for adult chronic diseases

Electroconvulsive therapy combined with esketamine improved depression through PI3K/AKT/GLT-1 pathway

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