Universal Hepatitis B Vaccination in Adults Aged 19–59 Years: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2022

Weng, Mark K.; Doshani, Mona; Khan, Mohammed A.; Frey, Sharon E.; Ault, Kevin A.; Moore, Kelly L.; Hall, Eric W.; Morgan, Rebecca L.; Campos‐Outcalt, Doug; Wester, Carolyn; Nelson, Noele P.

doi:10.15585/mmwr.mm7113a1

Cited by 94 publications

(93 citation statements)

References 15 publications

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“…We tested this hypothesis in our study using HCWs’ hepatitis B and Ebola vaccination status to fit the local Sierra Leonean context. Hepatitis B immunization is recommended for all adults, including HCWs [ 48 ]; we, therefore, used hepatitis B vaccination status as a marker for compliance with required routine vaccinations. Ebola vaccination status was tested as a surrogate for HCWs’ attitudes towards novel or emerging communicable diseases, given the recent history of an Ebola epidemic in the country [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Hesitancy among Healthcare Workers and Trainees in Freetown, Sierra Leone: A Cross-Sectional Study

et al. 2022

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Despite having safe and efficacious vaccines against COVID-19, vaccine hesitancy is widespread. Although a trusted source of information, vaccine hesitancy has been reported among healthcare professionals, yet few studies have explored this phenomenon in sub-Saharan Africa. We conducted a cross-sectional survey of healthcare professionals in Sierra Leone from January to March 2022. Measures included sociodemographic/health-related information and COVID-19-related concerns. From the responses, we constructed a hesitancy (VAX) score, with higher scores implying negative attitudes or unwillingness to vaccinate. Multivariate linear regression was used to access factors associated with vaccine hesitancy. Overall, 592 participants submitted responses (67.2% female, mean age 29 years, 5.6% physicians/pharmacists, 44.3% medical students, 29.2% nurses, 20.9% nursing students). The mean VAX score was 43.27 ± 8.77, with 60.1% of respondents classified as vaccine hesitant (>50th percentile) and 11.5% as highly hesitant (>75th percentile). Worries about unforeseen future effects (76.3%), a preference for natural immunity (59.5%), and profiteering/mistrust of health authorities (53.1%) were the most common concerns. Being a medical student (β = 0.105, p = 0.011) and previously refusing a recommended vaccine (β = 0.177, p < 0.001) were predictors of COVID-19 vaccine hesitancy. Our findings call for addressing vaccine hesitancy among healthcare professionals as an essential component of strategies aimed at increasing COVID-19 vaccine uptake in this setting.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Hesitancy among Healthcare Workers and Trainees in Freetown, Sierra Leone: A Cross-Sectional Study

et al. 2022

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“…Hepatitis Vaccination conducted a systematic review on HBV incidence, morbidity and mortality, and vaccine-related adverse events. 10 From 2011 to 2019, the rate of acute HBV cases increased by over 42% among those aged 40-59 years. Vaccination coverage among adults over 19 years was low (self-reported 30% in 2018) and lower for adults aged ≥50 years (19.1%), even among those with risk factors.…”

Section: Perspectivesmentioning

confidence: 99%

“…Prevailing hepatitis B virus (HBV) vaccination recommendations in the USA included vaccinating adults aged 19–59 years if they had risk factors for HBV exposure. The US Advisory Committee on Hepatitis Vaccination conducted a systematic review on HBV incidence, morbidity and mortality, and vaccine-related adverse events 10. From 2011 to 2019, the rate of acute HBV cases increased by over 42% among those aged 40–59 years.…”

Section: Universal Hepatitis B Vaccination Recommended For All Adults...mentioning

confidence: 99%

Research news in clinical context

Tan¹,

Daskalopoulou

Thomson-Glover

2022

Sex Transm Infect

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“…Recombinant hepatitis B vaccine can stimulate the body to produce protective antibodies and can be used to prevent all hepatitis B virus subtypes. The Hepatitis B vaccine showed well-established safety and effectiveness (5,6). Clinical .…”

Section: Introductionmentioning

confidence: 99%

Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world

Zhang

et al. 2022

Front. Pediatr.

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ObjectivesThe hepatitis B vaccine comprises hepatitis B surface antigen (HBsAg) produced by transgenic yeast cells. There are few serious adverse events (SAE) reports after Hepatitis B vaccination.MethodsThe authors searched the Chinese legal documents database for all SAE with Hepatitis B vaccination from January 2010 to January 2022.ResultsAll seven patients received yeast-derived recombinant hepatitis B vaccine. Three cases of myocarditis (death), 2 cases of interstitial pneumonia (death), and 2 cases of encephalitis. The mean time of onset of SAE was 8.3 ± 4.3 h after vaccination.ConclusionThe mechanism of vaccine-induced myocarditis may come from immune protein reactions. Based on the experience of Hepatitis B vaccine adverse events, we present new insights into the mechanism of myocarditis caused by the COVID-19 vaccine.

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Universal Hepatitis B Vaccination in Adults Aged 19–59 Years: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2022

Cited by 94 publications

References 15 publications

COVID-19 Vaccine Hesitancy among Healthcare Workers and Trainees in Freetown, Sierra Leone: A Cross-Sectional Study

COVID-19 Vaccine Hesitancy among Healthcare Workers and Trainees in Freetown, Sierra Leone: A Cross-Sectional Study

Research news in clinical context

Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world

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