United European Gastroenterology evidence‐based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)

Abstract

The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.

Endoscopic ultrasound (EUS) guided fine needle biopsy (FNB) with the Procore™ needle provides inadequate material for the histological diagnosis of early chronic pancreatitis

“…Chronic pancreatitis is characterized by the presence of a chronic infiltration of inflammatory cells and the progressive loss of acinar cells which are replaced by fibrosis. However, due to the absence of histology, the diagnosis of chronic pancreatitis relies on the demonstration of morphological abnormalities suggestive of pancreatic fibrosis (20,26,27). This makes the diagnosis at an early stage of the disease challenging, as well as the differential diagnosis with regard to similar conditions like pancreatopathy (7).…”

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

“…CP was diagnosed on the basis of morphological diagnostic criteria [23,24]. Abdominal ultrasonography (US) and computed tomography (CT) were performed in all patients.…”

Diseases of the Pancreas

“…Perfusion MRI, DWI, and FDG/PET can be helpful in such cases. Nevertheless, the common clinical presentation with chronic abdominal pain in chronic pancreatitis does not correlate very well with imaging findings [26][27][28][29][30]. …”