Unilateral, linear, zosteriform epidermal nevus with acantholytic dyskeratosis

Abstract

An infant has a nevus unius lateris with the histopathologic condition of acantholytic dyskeratosis. Similar cases have, in the past, been classified as unilateral Darier's disease. Since it is now recognized that the pathologic changes of acantholytic dyskeratosis are not specific for a given disease entity, we believe the concept of unilateral keratosis follicularis deserves reevaluation.

Localization of the Gene for Darier Disease to a 5-cM Interval on Chromosome 12q

“…These include, among others, Grover disease (a transient non-hereditary papular eruption limited to the chest of middle-aged to older men [15], warty dyskeratomas (solitary papules ofthe scalp or oral mucosa [16], and a subset of epidermal nevi [17]. This suggests that the histologic reaction pattern seen in Darier disease can be precipitated by a variety of stimuli including a genetic defect.…”

Histologic Changes Resembling the Vernicous Phase of Incontinentia Pigmenti Within Epidermal Nevi: Report of Two Cases

“…In addition to displaying varying stages of epidermal differentiation, the histopathology of epidermal nevi may mimic other clinical entities such as seborrheic keratosis (2), acanthosis nigricans (3), Darier's disease (acantholytic dyskeratosis) (4,5), buUous ichthyosis (epidermolytic hyperkeratosis) (6,7), porokeratosis (8), comedonal acne (9), and psoriasis, eczematous dermatitis, or lichen simplex chronicus (10). Furthermore, a nevus may exhibit more than one histopathologic pattem in different topographic sites or at different times (1).…”