Unilateral hyperkeratosis of the nipple: the response to cryotherapy

Nevoid hyperkeratosis of the nipple and/or areola: a report of two cases and a review of the literature

“…The observation that acanthosis nigricans, which is histologically similar to nevoid hyperkeratosis, has appeared after DES therapy is further support for this theory. 18 Additional support for this theory comes from reports of patients whose lesions began with puberty, 11 began with pregnancy, 9,10 or changed from a unilateral to a bilateral distribution with pregnancy. 3,13 Rodallec et al .…”

“…Occasionally, the lesions appear verrucous. 4,5,[8][9][10][11] Generally, erythema, induration and discharge do not occur. The lesions are often bilateral; however, there are several cases of unilateral nevoid hyperkeratosis.…”

“…The lesions are often bilateral; however, there are several cases of unilateral nevoid hyperkeratosis. 3,5,9,12 Some cases of unilateral nevoid hyperkeratosis have become bilateral after pregnancy. 3,13 The lesions may involve the nipple, the areola, or both.…”

“…Typically, the lesions are not bothersome to the patient with the exception of their undesirable appearance. 9 On occasion an affected patient may experience pruritus. The lesions usually do not interfere with breast function, although Perez-Izquierdo et al .…”

Nevoid Hyperkeratosis of the Areola in Men: Response to Cryotherapy

“…Vestey and Bunney [12]reported cosmetically satisfactory results with cryotherapy applied in five sessions. Surgical excision [4, 7]of the areolae may be performed if the patient is greatly disturbed by the cosmetic appearance.…”