Uniaxial and Multiaxial Fatigue Life Prediction of the Trabecular Bone Based on Physiological Loading: A Comparative Study

Januddi, Fatihhi; Harun, Muhamad Noor; Kadir, Mohammed Rafiq Abdul; Abdullah, Jaafar; Kamarul, Tunku; Öchsner, Andreas; Syahrom, Ardiyansyah

doi:10.1007/s10439-015-1305-8

Cited by 18 publications

(23 citation statements)

References 56 publications

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“…To study the effect of multiaxial loading based on physiological loading condition, sample of trabecular bone were loaded by multiaxial fatigue and compared to those loaded by uniaxial fatigue of the same sample. Nonlinear simulation was used which included plasticity in stress-strain curve as basis in modelling fatigue under LCF and HCF effects [3]. This modelling is normally developed as strain-based approach [24], [25] and thus can be applied directly to estimate fatigue failure of trabecular bone.…”

Section: Sample Preparation and µCt Imagingmentioning

confidence: 99%

“…Thus, in order to make accurate predictions related to the trabecular behaviour in vivo, this plasticity based model is required. The validity and comparison of the model was made with Fatihhi et al [3] and all the constitutive parameters for fatigue were taken from this previous study.…”

Section: Finite Element (Fe) Analysis Of Fatigue Loadingmentioning

confidence: 99%

“…Furthermore, the simulation is non-destructive and allows for better representation of localized trabecular level as variation in the properties of model can be reduced. In this study, FE analysis to investigate the behaviour of bovine trabecular bone model under fatigue simulation was first conducted to validate the assigned parameters and its subsequent fatigue response with the recorded data from experimental analysis [3]. The investigation was extended to evaluate the effect of off-axis loading on the fatigue behaviour of the trabecular bone model.…”

Section: Finite Element (Fe) Analysis Of Fatigue Loadingmentioning

confidence: 99%

“…As fatigue failure in bones contribute to significant clinical implications, studies and investigations to better comprehend fatigue failure in bones are required. Factors affecting fatigue strength of bone include the loading mechanism, frequency, strain rate, age, anatomic site, stiffness, density and temperature, as well as the microstructure of the bone [3], [5], [8]- [11].…”

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Fatigue behavior of trabecular bone orientation

Januddi

Harun

Abdullah

et al. 2020

Preprint

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The present study reports the anisotropy effects of uniaxial and multiaxial loading on cancellous bone in order to mimic true physiological conditions as well as pathological reactions and thereby provides improved data that represents clinical and real life conditions. Cancellous bone samples were CT-scanned for morphological analysis and model construction. The models were then computationally loaded on three different directions; horizontal, vertical, and at 45°. Lower BV/TV, Tb.Th, and Conn.D resulted in lower number of cycles to failure, regardless to the loading conditions. However, the number of cycles to failure was found to be negatively correlated to the value of structural model index. Dramatic increased in effective plastic strain and decrease in cycles to failure were demonstrated by the cancellous bone models under multiaxial loading. The reduction of fatigue life was five times lower in multiaxial condition in comparison to the fatigue life under uniaxial loading. Off-axis orientation effect on the fatigue life of the trabecular bone was demonstrated the worst in horizontal trabecular bone model. Effective plastic strain was recorded the highest in horizontal model, while the model at 45º demonstrated 1.6 times higher effective plastic strain than the vertical ones. This is due to several numbers of thin trabeculae which are susceptible to fatigue at higher stress concentration. In conclusion, the anisotropic effect of uniaxial and multiaxial loading onto the mechanical behaviour of bovine cancellous bone was demonstrated throughout this study. It is apparent that multiaxial with off-axis forces are important to be considered as the loading direction manifests the fatigue lifetime of cancellous bone.

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Section: Sample Preparation and µCt Imagingmentioning

confidence: 99%

Section: Finite Element (Fe) Analysis Of Fatigue Loadingmentioning

confidence: 99%

Section: Finite Element (Fe) Analysis Of Fatigue Loadingmentioning

confidence: 99%

mentioning

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Fatigue behavior of trabecular bone orientation

Januddi

Harun

Abdullah

et al. 2020

Preprint

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“…It has been speculated that the gradient of bone volume fraction between sclerotic and non-sclerotic bone may lead to focally increased strains with subsequent damage accumulation (Riggs et al 1999a). However, sclerosis may be protective, as higher bone volume fraction of trabecular bone is associated with increased fatigue resistance (Rapillard et al 2006;Fatihhi et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Subchondral bone morphology in the metacarpus of racehorses in training changes with distance from the articular surface but not with age

et al. 2018

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The repetitive large loads generated during high-speed training and racing commonly cause subchondral bone injuries in the metacarpal condyles of racehorses. Adaptive bone modelling leads to focal sclerosis at the site of highest loading in the palmar aspect of the metacarpal condyles. Information on whether and how adaptive modelling of subchondral bone changes during the career of a racehorse is sparse. The aim of this cross-sectional study was to describe the changes in subchondral bone micromorphology in the area of highest loading in the palmar aspect of the metacarpal condyle in thoroughbred racehorses as a function of age and training. Bone morphology parameters derived from micro-CT images were evaluated using principal component analysis and mixed-effects linear regression models. The largest differences in micromorphology were observed in untrained horses between the age of 16 and 20 months. Age and duration of a training period had no influence on tissue mineral density, bone volume fraction or number and area of closed pores to a depth of 5.1 mm from the articular surface in 2- to 4-year-old racehorses in training. Horses with subchondral bone injuries had more pores in cross-section compared with horses without subchondral bone injuries. Differences in bone volume fraction were due to the volume of less mineralised bone. Tissue mineral density increased and bone volume fraction decreased with increasing distance from the articular surface up to 5.1 mm from the articular surface. Further research is required to elucidate the biomechanical and pathophysiological consequences of these gradients of micromorphological parameters in the subchondral bone.

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Mathematical modelling of bone adaptation of the metacarpal subchondral bone in racehorses

Hitchens

Pivonka

Malekipour

et al. 2018

Biomech Model Mechanobiol

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In Thoroughbred racehorses, fractures of the distal limb are commonly catastrophic. Most of these fractures occur due to the accumulation of fatigue damage from repetitive loading, as evidenced by microdamage at the predilection sites for fracture. Adaptation of the bone in response to training loads is important for fatigue resistance. In order to better understand the mechanism of subchondral bone adaptation to its loading environment, we utilised a square root function defining the relationship between bone volume fraction [Formula: see text] and specific surface [Formula: see text] of the subchondral bone of the lateral condyles of the third metacarpal bone (MCIII) of the racehorse, and using this equation, developed a mathematical model of subchondral bone that adapts to loading conditions observed in vivo. The model is expressed as an ordinary differential equation incorporating a formation rate that is dependent on strain energy density. The loading conditions applied to a selected subchondral region, i.e. volume of interest, were estimated based on joint contact forces sustained by racehorses in training. For each of the initial conditions of [Formula: see text] we found no difference between subsequent homoeostatic [Formula: see text] at any given loading condition, but the time to reach equilibrium differed by initial [Formula: see text] and loading condition. We found that the observed values for [Formula: see text] from the mathematical model output were a good approximation to the existing data for racehorses in training or at rest. This model provides the basis for understanding the effect of changes to training strategies that may reduce the risk of racehorse injury.

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Uniaxial and Multiaxial Fatigue Life Prediction of the Trabecular Bone Based on Physiological Loading: A Comparative Study

Cited by 18 publications

References 56 publications

Fatigue behavior of trabecular bone orientation

Fatigue behavior of trabecular bone orientation

Subchondral bone morphology in the metacarpus of racehorses in training changes with distance from the articular surface but not with age

Mathematical modelling of bone adaptation of the metacarpal subchondral bone in racehorses

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