Unfractionated or low-molecular weight heparin for induction of remission in ulcerative colitis

Oral administration of low‐molecular‐weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

“…Although several studies have already illustrated the beneficial effect of LMWH on UC, there has been little research done on how LMWH plays this role. Owing to its strong negative charge, LMWH is not easily absorbed from the intestinal lumen into the circulation and thus cannot directly interact with immune cells (Chande et al, 2015). Because enzymes that degrade heparin are not expressed in the human intestine, oral LMWH can easily reach colon without degradation (X. Zhou et al, 2019).…”

Oral administration of low‐molecular‐weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

“…Although several studies have already illustrated the beneficial effect of LMWH on UC, there has been little research done on how LMWH plays this role. Owing to its strong negative charge, LMWH is not easily absorbed from the intestinal lumen into the circulation and thus cannot directly interact with immune cells (Chande et al, 2015). Because enzymes that degrade heparin are not expressed in the human intestine, oral LMWH can easily reach colon without degradation (X. Zhou et al, 2019).…”

Thrombin Induced Apoptosis through Calcium-Mediated Activation of Cytosolic Phospholipase A2 in Intestinal Myofibroblasts

“…Previous studies have suggested that thrombin could be a therapeutic target for the treatment of intestinal bowel disease (IBD) (Chande et al, 2008;Scaldaferri et al, 2011). Thrombin release and its activity increased with the severity of inflammation in IBD patients (Denadai-Souza et al, 2018;Motta et al, 2021b).…”

Central venous sinus thrombosis in a young girl with ulcerative colitis

“…Thrombosis in IBD involves both systemic TE and localised microthrombi in the vasculature of the intestine 5. Notably, there is evidence that microvascular thrombosis may be a part of the disease process in UC as treatment with enteral extended colon-release tablets of LMWH has shown to be beneficial 6. Nylund et al considered 96% of all paediatric inpatient visits in the USA at a stratified random sample across five time periods: 1997, 2000, 2003, 2006 and 2009.…”

Oral administration of low‐molecular‐weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

“…Although several studies have already illustrated the beneficial effect of LMWH on UC, there has been little research done on how LMWH plays this role. Owing to its strong negative charge, LMWH is not easily absorbed from the intestinal lumen into the circulation and thus cannot directly interact with immune cells (Chande et al, 2015). Because enzymes that degrade heparin are not expressed in the human intestine, oral LMWH can easily reach colon without degradation (X. Zhou et al, 2019).…”

Thrombin Induced Apoptosis through Calcium-Mediated Activation of Cytosolic Phospholipase A2 in Intestinal Myofibroblasts

“…Previous studies have suggested that thrombin could be a therapeutic target for the treatment of intestinal bowel disease (IBD) (Chande et al, 2008;Scaldaferri et al, 2011). Thrombin release and its activity increased with the severity of inflammation in IBD patients (Denadai-Souza et al, 2018;Motta et al, 2021b).…”

Central venous sinus thrombosis in a young girl with ulcerative colitis

“…Thrombosis in IBD involves both systemic TE and localised microthrombi in the vasculature of the intestine 5. Notably, there is evidence that microvascular thrombosis may be a part of the disease process in UC as treatment with enteral extended colon-release tablets of LMWH has shown to be beneficial 6. Nylund et al considered 96% of all paediatric inpatient visits in the USA at a stratified random sample across five time periods: 1997, 2000, 2003, 2006 and 2009.…”

Oral administration of low‐molecular‐weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

“…Although several studies have already illustrated the beneficial effect of LMWH on UC, there has been little research done on how LMWH plays this role. Owing to its strong negative charge, LMWH is not easily absorbed from the intestinal lumen into the circulation and thus cannot directly interact with immune cells (Chande et al, 2015). Because enzymes that degrade heparin are not expressed in the human intestine, oral LMWH can easily reach colon without degradation (X. Zhou et al, 2019).…”

Thrombin Induced Apoptosis through Calcium-Mediated Activation of Cytosolic Phospholipase A2 in Intestinal Myofibroblasts

“…Previous studies have suggested that thrombin could be a therapeutic target for the treatment of intestinal bowel disease (IBD) (Chande et al, 2008;Scaldaferri et al, 2011). Thrombin release and its activity increased with the severity of inflammation in IBD patients (Denadai-Souza et al, 2018;Motta et al, 2021b).…”

Central venous sinus thrombosis in a young girl with ulcerative colitis

“…Thrombosis in IBD involves both systemic TE and localised microthrombi in the vasculature of the intestine 5. Notably, there is evidence that microvascular thrombosis may be a part of the disease process in UC as treatment with enteral extended colon-release tablets of LMWH has shown to be beneficial 6. Nylund et al considered 96% of all paediatric inpatient visits in the USA at a stratified random sample across five time periods: 1997, 2000, 2003, 2006 and 2009.…”