Unexpected One‐Pot Formation of Lactam Oximes from Amino‐Hydroxamic Esters

Abstract

The unexpected one‐pot intramolecular formation of lactam oximes from the corresponding amino‐hydroxamic ester in the presence of amine is described. Several reaction parameters were studied, and the importance of the base and the size of the resulting cycle were shown. This reaction can thus be considered as a new synthetic approach to prepare lactam oximes in a one‐pot manner and in mild conditions.