Unexpected Histological Findings in Pterygium

Degrassi, Marco; Piantanida, Andrea; Nucci, Paolo

doi:10.1097/00006324-199312000-00012

Cited by 14 publications

(12 citation statements)

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“…Although the pathogenesis of pterygia is still poorly understood, epidemiologic evidence suggests that environmental stress may have a role 1,3. Recently, several cytokines such as TNF-α, fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β), have been localized to both resident and inflammatory cells in pterygia 2,8.…”

Section: Discussionmentioning

confidence: 99%

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Cyclooxygenase-2 expression in primary and recurrent pterygium

Karahan¹,

Başpınar²,

Çiriş³

et al. 2008

Indian J Ophthalmol

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Background:Pterygia are common, benign, fibrovascular, and infiltrative processes of the corneo- conjunctival junction of unknown pathogenesis. Cyclooxygenase-2 (COX-2) mediates the rate-limiting step in arachidonic acid metabolism. Extensive evidence indicates that the COX-2 prostanoid pathway is involved in inflammation. The aim of the study was to document the immunohistochemical expression of COX-2 in primary and recurrent pterygia.Materials and Methods:In this study, 21 primary pterygia and 12 recurrent pterygia from subjects undergoing pterygium surgery and six normal corneal-scleral tissue specimens were studied immunohistochemically for COX-2 expression.Results:COX-2 was expressed in primary pterygia and recurrent pterygia specimens. There was a statistically significant difference in COX-2 expressions in fibroblasts between primary and recurrent pterygium cases (P = 0.001). There were statistically significant differences in COX-2 expressions in surface epithelium (P = 0.028) and stromal inflammatory cells (P=0.000) between control tissues and primary pterygia tissues. We also detected statistically significant differences in COX-2 expressions in surface epithelium (P=0.000), stromal fibroblasts P=0.000 (stromal fibroblasts and inflammatory cells), vessels (P = 0.027) and inflammatory cells (P=0.001) between control tissues and recurrent pterygia tissues.Conclusions:This is the first study to document the expression of COX-2 in primary and recurrent pterygia. In our opinion after excision of pterygia, fibroblastic proliferation continues and this contributes to recurrence.

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Section: Discussionmentioning

confidence: 99%

“…Pterygia are histopathologically fibrovascular proliferations. This expansiveness of fibrovascular proliferation is considered as a convenient morphological index for evaluation of recurrence risk after surgical treatment 1-3. Pterygia usually recur after surgical excision 4.…”

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confidence: 99%

Cyclooxygenase-2 expression in primary and recurrent pterygium

Karahan¹,

Başpınar²,

Çiriş³

et al. 2008

Indian J Ophthalmol

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“…Recurrent pterygium usually grows more aggressively and requires more sophisticated surgery 2. Fibroblasts from pterygia have been shown to behave as neoplastic cells in vitro3 and random histological examination has revealed neoplastic features 4. Polymerase chain reaction (PCR) studies have revealed viral presence (herpes simplex virus, cytomegalovirus, human papillomavirus) in pterygia 5…”

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confidence: 99%

Evaluation of loss of heterozygosity and microsatellite instability in human pterygium: clinical correlations

Detorakis

Sourvinos

Tsamparlakis

et al. 1998

British Journal of Ophthalmology

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Aims-To evaluate the incidence of loss of heterozygosity (LOH) and microsatellite instability (MI) in pterygia and their possible correlation with clinical variables. Methods-50 pterygia, blood, and conjunctival specimens were obtained. A personal and family history was recorded for each patient. Amplification of 15 microsatellite markers at regions 17p, 17q, 13q, 9p, and 9q was performed using the polymerase chain reaction. The electrophoretic pattern of DNA from pterygia was compared with the respective pattern from blood and conjunctiva. Results-LOH incidence was the highest at 9p (48%), followed by 17q (42%). Only three cases displayed MI. LOH incidence at individual markers was positively correlated with recurrence (D9S59, p=0.11 and D9S270, p=0.16), family history of neoplasia (D13S175, p=0.09), altitude of present residence ( D9S112, p=0.1), duration of the existence of pterygium (D9S144, p=0.06), and inversely correlated with age (D9S59, p=0.09). Concerning chromosome arms, LOH was positively correlated with the altitude of present residence (13q and 17p, p=0.03) and duration of the existence of pterygium (13q and 17p, p=0.09). Conclusions-LOH is a common event whereas MI is a very uncommon one at the examined markers in pterygium, indicating the presence of putative tumour suppressor genes implicated in the aetiopathogenesis of the disease. The fact that LOH at 9q31-33 was more frequent in recurrent pterygia and also correlated with known risk factors such as young age and high altitude of residence, implies a possible predictive value of this finding for postoperative recurrence. (Br J Ophthalmol 1998;82:1324-1328

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“…In a study by Sevel and Sealy, 6 investigating the association of pterygium with CIN and SCC, 12 cases of SCC and 17 cases of CIN were shown to arise in 100 pterygium cases, indicating that distinguishing a "reactive pterygium" from CIN and SCC may be difficult. Similarly, Degrassi et al 7 presented a case report in which the pathologic examination of an apparent pterygium showed the presence of CIN in a 53-year-old man. In another study, Akpek et al 8 showed that ocular surface malignancies may involve the conjunctiva diffusely and present as chronic conjunctivitis.…”

Section: Discussionmentioning

confidence: 88%